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Anti-colorectal cancer effect of interleukin-2 and interferon-β fusion gene driven by carcinoembryonic antigen promoter

Authors Wang Y, Wang M, Li Y

Received 30 September 2015

Accepted for publication 22 January 2016

Published 30 May 2016 Volume 2016:9 Pages 3259—3267

DOI https://doi.org/10.2147/OTT.S97444

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Jia Fan

Peer reviewer comments 3

Editor who approved publication: Dr Faris Farassati


Yan Wang, Mengchun Wang, Yan Li

Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China

Abstract: This study was designed to investigate the antitumor effects of combined interleukin-2/interferon-β-based gene therapy in colorectal cancer. Transfection of the fusion gene expression plasmid induced significant apoptosis of Lovo cells. Additionally, the fusion gene exhibited strong inhibitory activity against tumor growth and apoptosis when being injected into the nude mice implanted with human colon cancer cells. Furthermore, the tail-vein injection showed a more notable effect than direct injection into tumor. These results suggest that the combined interleukin-2/interferon-β-based gene therapy with the carcinoembryonic antigen promoter might be an effective antitumor strategy.

Keywords: apoptosis, interferon-β, interleukin-2, antitumor, combined gene therapy

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