Back to Browse Journals » International Journal of Nanomedicine » Volume 7

Anti-CD30-targeted gold nanoparticles for photothermal therapy of L-428 Hodgkin's cell

Authors Qu X, Yao C, Wang J, Li Z, Zhang Z

Received 21 August 2012

Accepted for publication 22 October 2012

Published 14 December 2012 Volume 2012:7 Pages 6095—6103


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Xiaochao Qu,1,2,* Cuiping Yao,2,* Jing Wang,2 Zheng Li,2 Zhenxi Zhang,2

1Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China; 2Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China

*These authors contributed equally to this work

Purpose: Due to the efficient bioconjugation and highly photothermal effect, gold nanoparticles can stain receptor-overexpressing cancer cells through specific targeting of ligands to receptors, strongly absorb specific light and efficiently convert it into heat based on the property of surface plasmon resonance, and then induce the localized protein denaturation and cell death.
Methods: Two gold nanoparticle–antibody conjugates, gold-BerH2 antibody (anti-CD30 receptor) and gold-ACT1 antibody (anti-CD25-receptor), were synthesized. Gold-BerH2 conjugates can specifically bind to the surface of L-428 Hodgkin's cells, and gold-ACT1 conjugates were used for the control. The gold nanoparticle-induced L-428 cell-killing experiments were implemented with different experimental parameters.
Results: At a relatively low concentration of gold and short incubation time, the influence of cytotoxicity of gold on cell viability can be overlooked. Under laser irradiation at suitable power, the high killing efficiency of gold-targeted L-428 cells was achieved, but little damage was done to nontargeted cancer cells.
Conclusion: Gold nanoparticle-mediated photothermal therapy provides a relatively safe therapeutic technique for cancer treatment.

Keywords: gold nanoparticle–antibody conjugates, surface plasmon resonance, laser irradiation, selective destruction, photothermal treatment, cancer

Erratum for this paper has been published

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] View Full Text [HTML] 


Other article by this author:

Anti-CD30-targeted gold nanoparticles for photothermal therapy of L-428 Hodgkin’s cell [Erratum]

Qu X, Yao C, Wang J, Li Z, Zhang Z

International Journal of Nanomedicine 2013, 8:1635-1636

Published Date: 26 April 2013

Readers of this article also read:


Cárdenas WH, Mamani JB, Sibov TT, Caous CA, Amaro E Jr, Gamarra LF

International Journal of Nanomedicine 2012, 7:5107-5108

Published Date: 21 September 2012

Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles

Roohi F, Lohrke J, Ide A, Schuetz G, Dassler K

International Journal of Nanomedicine 2012, 7:4447-4458

Published Date: 10 August 2012

Blood–brain barrier: a real obstacle for therapeutics

Shiekh FA

International Journal of Nanomedicine 2012, 7:4065-4067

Published Date: 27 July 2012

Biomimetic component coating on 3D scaffolds using high bioactivity of mesoporous bioactive ceramics

Yun HS, Kim SH, Khang DW, Choi JI, Kim HH, Kang MJ

International Journal of Nanomedicine 2011, 6:2521-2531

Published Date: 21 October 2011

SERS-based nanobiosensing for ultrasensitive detection of the p53 tumor suppressor

Domenici F, Bizzarri AR, Cannistraro S

International Journal of Nanomedicine 2011, 6:2033-2042

Published Date: 19 September 2011

Efficacy of intravenous amphotericin B-polybutylcyanoacrylate nanoparticles against cryptococcal meningitis in mice

Xu N, Gu JL, Zhu YJ, Wen H, Ren QS, Chen JH

International Journal of Nanomedicine 2011, 6:905-913

Published Date: 28 April 2011

Probing the mechanical properties of TNF-α stimulated endothelial cell with atomic force microscopy

Sei-Young Lee, Ana-Maria Zaske, Tommaso Novellino, et al

International Journal of Nanomedicine 2011, 6:179-195

Published Date: 24 January 2011

Synthesis and characterization of silver/talc nanocomposites using the wet chemical reduction method

Kamyar Shameli, Mansor Bin Ahmad, Wan Zin Wan Yunus, et al

International Journal of Nanomedicine 2010, 5:743-751

Published Date: 29 September 2010

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010