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Anterior-Segment Optical Coherence Tomography–Guided Measurement Of A Melting Ulcer For Follow-Up Of Corneoscleral Thinning Progression

Authors Cohen S, Tucker Y, Guttman S, Bubis E, Rubinstein Y, Skaat A, Sher I, Rotenstreich Y

Received 11 June 2019

Accepted for publication 16 August 2019

Published 7 November 2019 Volume 2019:12 Pages 335—338

DOI https://doi.org/10.2147/IMCRJ.S219132

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Shai Cohen,1,2 Yisroel Tucker,3 Sharon Guttman,2,4 Ettel Bubis,2,3 Yair Rubinstein,3 Alon Skaat,2,5 Ifat Sher,2,3 Ygal Rotenstreich2,3

1Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel; 2Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; 3Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel; 4Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel; 5Sam Rothberg Glaucoma Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel

Correspondence: Ygal Rotenstreich
Goldschleger Eye Institute, Sheba Medical Center, Derech Sheba 2, Tel-Hashomer, Ramat Gan, Israel
Tel +972-3-5308132
Email Ygal.Rotenstreich@sheba.health.gov.il

Purpose: To evaluate the feasibility of using anterior-segment optical coherence tomography (AS-OCT) for three-dimensional assessment of corneoscleral thinning progression in ulcers after pterygium removal.
Methods: A patient with corneoscleral melting after pterygium removal surgery and mitomycin C treatment was evaluated using AS-OCT imaging of the corneoscleral ulcer at five consecutive time points, up to 2 years. AS-OCT scans of 8.3×5.6 mm (15°×10°) containing 41 B-scans spaced 139 μm apart were performed monthly for 4 months and then at 2 years following pterygium removal. A single B-scan was comprised of 768 A-scans. Ten B-scans of the same position were averaged in a single AS-OCT image. The area of ulcer’s section (AUS) was measured in seven fixed landmarks through a horizontally aligned plane in order to provide an estimation of the three-dimensional size of the lesion.
Results: The AUS in the two superior locations increased during the follow-up period to an average of 114% at 2 years compared to the initial visit. In the other five locations (three midline and two inferior), the AUS decreased and was on average 64% in the midline and 29% in the inferior locations at 24 months.
Conclusion: AS-OCT provided a readily available assessment of the lesion’s three-dimensional size during repeated follow-ups and identification of localized areas at higher risk for perforation. This method may potentially be useful for corneal surface pathologies requiring repeated follow-ups and may aid in decision-making regarding corneal thickness based on an accurate measurement.

Keywords: anterior segment optical coherence tomography, corneoscleral melt, pterygium, corneoscleral thinning, ulcer follow up


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