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Animal models of well-differentiated/dedifferentiated liposarcoma: utility and limitations

Authors Codenotti S, Mansoury W, Pinardi L, Monti E, Marampon F, Fanzani A

Received 16 February 2019

Accepted for publication 4 June 2019

Published 3 July 2019 Volume 2019:12 Pages 5257—5268

DOI https://doi.org/10.2147/OTT.S175710

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Sanjay Singh


Silvia Codenotti,1 Walaa Mansoury,1 Luca Pinardi,1 Eugenio Monti,1 Francesco Marampon,2 Alessandro Fanzani1

1Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; 2Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy

Abstract: Liposarcoma is a malignant neoplasm of fat tissue. Well-differentiated and dedifferentiated liposarcoma (WDL/DDL) represent the two most clinically observed histotypes occurring in middle-aged to older adults, particularly within the retroperitoneum or extremities. WDL/DDL are thought to represent the broad spectrum of one disease, as they are both associated with the amplification in the chromosomal 12q13-15 region that causes MDM2 and CDK4 overexpression, the most useful predictor for liposarcoma diagnosis. In comparison to WDL, DDL contains additional genetic abnormalities, principally coamplifications of 1p32 and 6q23, that increase recurrence and metastatic rate. In this review, we discuss the xenograft and transgenic animal models generated for studying progression of WDL/DDL, highlighting utilities and pitfalls in such approaches that can facilitate or impede the development of new therapies.

Keywords: liposarcoma, transgenic animal model, xenograft

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