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Animal models of systemic sclerosis: their utility and limitations

Authors Artlett C

Received 25 March 2014

Accepted for publication 29 April 2014

Published 1 July 2014 Volume 2014:6 Pages 65—81


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Carol M Artlett

Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA

Abstract: Without doubt, animal models have provided significant insights into our understanding of the rheumatological diseases; however, no model has accurately replicated all aspects of any autoimmune disease. Recent years have seen a plethora of knockouts and transgenics that have contributed to our knowledge of the initiating events of systemic sclerosis, an autoimmune disease. In this review, the focus is on models of systemic sclerosis and how they have progressed our understanding of fibrosis and vasculopathy, and whether they are relevant to the pathogenesis of systemic sclerosis.

Keywords: systemic sclerosis, animal models, vasculopathy, fibrosis, chicken, mouse

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