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Animal models of pancreatic cancer and their application in clinical research

Authors Weidenhofer J, Colvin E, Bond D, Scarlett C

Received 6 May 2016

Accepted for publication 29 July 2016

Published 25 August 2016 Volume 2016:6 Pages 31—39


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Eileen O'Reilly

Judith Weidenhofer,1,2 Emily K Colvin,3 Danielle R Bond,1,2,4 Christopher J Scarlett2,4

1School of Biomedical Sciences and Pharmacy, The University of Newcastle, Ourimbah, 2Cancer Program, Hunter Medical Research Institute, New Lambton, 3Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, 4Pancreatic Cancer Research Group, School of Environmental and Life Sciences, The University of Newcastle, Ourimbah, NSW, Australia

Abstract: Pancreatic cancer has one of the highest cancer-related mortality rates of all cancers, and despite worldwide efforts to identify new curative treatments, little improvement has been made toward disease-free survival rates. Due to the effect of a heterogeneous disease phenotype in an organ where desmoplastic effects modify tumor behavior and capacity to deliver chemotherapeutics, it is clear that accurate in vivo models are imperative for the understanding of this disease, to identify and test novel therapeutics, and to assist in identifying biomarkers. This review addresses the currently available mouse models of pancreatic ductal adenocarcinoma, in particular genetically engineered and patient-derived xenograft models, focusing on their utility in the drug discovery pipeline.

Keywords: pancreatic cancer, mouse models, genetically engineered, patient-derived, orthotopic, xenograft

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