Back to Journals » International Journal of General Medicine » Volume 9

Animal models of myasthenia gravis: utility and limitations

Authors Mantegazza R, Cordiglieri C, Consonni A, Baggi F

Received 29 September 2015

Accepted for publication 27 November 2015

Published 4 March 2016 Volume 2016:9 Pages 53—64

DOI https://doi.org/10.2147/IJGM.S88552

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Weirui Guo

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Renato Mantegazza, Chiara Cordiglieri, Alessandra Consonni, Fulvio Baggi

Neurology IV Unit, Neuroimmunology and Neuromuscular Disorders, Foundation IRCCS Neurological Institute “Carlo Besta”, Milan, Italy

Abstract: Myasthenia gravis (MG) is a chronic autoimmune disease caused by the immune attack of the neuromuscular junction. Antibodies directed against the acetylcholine receptor (AChR) induce receptor degradation, complement cascade activation, and postsynaptic membrane destruction, resulting in functional reduction in AChR availability. Besides anti-AChR antibodies, other autoantibodies are known to play pathogenic roles in MG. The experimental autoimmune MG (EAMG) models have been of great help over the years in understanding the pathophysiological role of specific autoantibodies and T helper lymphocytes and in suggesting new therapies for prevention and modulation of the ongoing disease. EAMG can be induced in mice and rats of susceptible strains that show clinical symptoms mimicking the human disease. EAMG models are helpful for studying both the muscle and the immune compartments to evaluate new treatment perspectives. In this review, we concentrate on recent findings on EAMG models, focusing on their utility and limitations.

Keywords: myasthenia gravis, autoimmunity, neuroimmunology, AChR

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]