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Animal models of contraception: utility and limitations

Authors Liechty E, Bergin I, Bell J

Received 5 February 2015

Accepted for publication 19 February 2015

Published 17 April 2015 Volume 2015:6 Pages 27—35

DOI https://doi.org/10.2147/OAJC.S58754

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Igal Wolman


Emma R Liechty,1 Ingrid L Bergin,1 Jason D Bell2

1Unit for Laboratory Animal Medicine, 2Program on Women's Health Care Effectiveness Research, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA

Abstract: Appropriate animal modeling is vital for the successful development of novel contraceptive devices. Advances in reproductive biology have identified novel pathways for contraceptive intervention. Here we review species-specific anatomic and physiologic considerations impacting preclinical contraceptive testing, including efficacy testing, mechanistic studies, device design, and modeling off-target effects. Emphasis is placed on the use of nonhuman primate models in contraceptive device development.

Keywords: nonhuman primate, preclinical, in vivo, contraceptive devices

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