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Analysis of the cumulative effect of schizophrenia-related single nucleotide polymorphisms

Authors Lozano R, Marín R, Freire I, Santacruz MJ, Pascual-García A

Received 22 April 2014

Accepted for publication 23 April 2014

Published 12 June 2014 Volume 2014:10 Pages 1079—1080

DOI https://doi.org/10.2147/NDT.S66657

Checked for plagiarism Yes

Roberto Lozano,1 Reyes Marín,2 Isabel Freire,2 María-Jesús Santacruz,2 Asunción Pascual-García2

1Pharmacy Department, 2Psychiatry Department, Hospital Real de Nuestra Señora de Gracia, Zaragoza, Spain

It is currently believed that predisposition for schizophrenia stems from the combined effect of multiple common polymorphisms. Thus, no genetic variant is considered to be fully responsible for the disease. For this reason, analysis of the cumulative effect of schizophrenia-related single nucleotide polymorphisms (SNPs) could provide information about the genetic mechanisms that underlie susceptibility.

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