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Analog insulin detemir for patients with type 1 and type 2 diabetes: a review

Authors Peterson G

Published 15 May 2009 Volume 2009:2 Pages 31—36

DOI https://doi.org/10.2147/DMSO.S3401

Review by Single-blind

Peer reviewer comments 3


Gregory E Peterson

Department of Internal Medicine, Des Moines University, USA

Objective: To review insulin detemir for clinical use to better manage patients with type 1 and type 2 diabetes.

Methods: A MEDLINE search, in English, from June 30, 2006 to December 1, 2008, using the terms “insulin analogs,” “insulin detemir” and “long-acting insulin analog.”

Results: Insulin detemir improves glycemic control, based on HbA1C reduction and fasting glucose levels, without increasing the risk of hypoglycemia and weight gain. Insulin detemir has lower glycemic variability, with less intra-subject variability in blood glucose levels in patients with type 1 and type 2 diabetes, without increasing the risk of hypoglycemia. When added to oral anti-diabetes agents (OADs) in type 2 diabetes, insulin detemir demonstrates superiority to other basal insulin options.

Conclusion: Insulin detemir appears to provide better glycemic control with a lower risk of hypoglycemia and less weight gain in the treatment of patients with type 1 and type 2 diabetes.

Keywords: type 1 diabetes, type 2 diabetes, insulin analogs, insulin detemir

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