Back to Journals » Gastrointestinal Cancer: Targets and Therapy » Volume 3

Anal cancer: current and future treatment strategies

Authors Chin JY, Hong TS, Wo JY

Received 13 September 2012

Accepted for publication 5 November 2012

Published 17 January 2013 Volume 2013:3 Pages 19—27

DOI https://doi.org/10.2147/GICTT.S25844

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Joanna Y Chin, Theodore S Hong, Jennifer Y Wo

Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA

Abstract: Anal cancer is a relatively rare malignancy, accounting for approximately 2% of gastrointestinal cancers. Concurrent chemoradiation with 5-fluorouracil/mitomycin remains the standard of care for the treatment of anal cancer. There is currently no proven role for platinum-based induction or adjuvant chemotherapy in anal cancer, even in cases of bulky disease. Multiple trials have shown that radiosensitization with concurrent chemotherapy is beneficial over radiation alone, and in particular, efforts to remove or substitute mitomycin from the chemoradiation regimen have been unsuccessful. Because local-regional control remains a challenge in the management of anal cancer, future studies will need to focus on radiation dose-escalation and/or addition of further chemotherapy or targeted agents. Patient selection, eg, with PET-CT or with biomarkers including HPV status, may be necessary to define patients who need more aggressive local treatment, ie, for patients with bulky disease, or to de-escalate treatment in others, ie, patients with early-stage, localized cancer.

Keywords: anal cancer, chemoradiation, IMRT

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Readers of this article also read:

Optimal delivery of male breast cancer follow-up care: improving outcomes

Ferzoco RM, Ruddy KJ

Breast Cancer: Targets and Therapy 2015, 7:371-379

Published Date: 23 November 2015

Profile of bevacizumab and its potential in the treatment of cervical cancer

Fisher CM, Schefter TE

OncoTargets and Therapy 2015, 8:3425-3431

Published Date: 19 November 2015

miR-195 is a key regulator of Raf1 in thyroid cancer

Wang F, Jiang C, Sun Q, Yan F, Wang L, Fu Z, Liu T, Hu F

OncoTargets and Therapy 2015, 8:3021-3028

Published Date: 20 October 2015

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Capecitabine in the management of colorectal cancer

Hirsch BR, Zafar SY

Cancer Management and Research 2011, 3:79-89

Published Date: 24 March 2011