Back to Browse Journals » Neuropsychiatric Disease and Treatment » Volume 4 » Issue 6

An update on the toxicity of Aβ in Alzheimer’s disease

Authors Jürgen Götz, Lars M Ittner, Nicole Schonrock, Roberto Cappai

Published 5 December 2008 Volume 2008:4(6) Pages 1033—1042


Review by Single-blind

Peer reviewer comments 9

Jürgen Götz1, Lars M Ittner1, Nicole Schonrock1, Roberto Cappai2

1Alzheimer’s and Parkinson’s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, NSW, Australia; 2Department of Pathology, The University of Melbourne, Victoria, Australia

Abstract: Alzheimer’s disease is characterized histopathologically by deposition of insoluble forms of the peptide Aβ and the protein tau in brain. Aβ is the principal component of amyloid plaques and tau of neurofibrillary tangles. Familial cases of AD are associated with causal mutations in the gene encoding the amyloid precursor protein, APP, from which the amyloidogenic Aβ peptide is derived, and this supports a role for Aβ in disease. Aβ can promote tau pathology and at the same time its toxicity is also tau-dependent. Aβ can adopt different conformations including soluble oligomers and insoluble fibrillar species present in plaques. We discuss which of these conformations exert toxicity, highlight molecular pathways involved and discuss what has been learned by applying functional genomics.

Keywords: amyloid, mitochondria, oligomer, proteomic, tau, transgenic

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Readers of this article also read:

Beneficial effects of multisensory and cognitive stimulation on age-related cognitive decline in long-term-care institutions

Oliveira TCG, Soares FC, Macedo LDD, Picanço-Diniz DLW, Bento-Torres NVO, Picanço-Diniz CW

Clinical Interventions in Aging 2014, 9:309-321

Published Date: 14 February 2014

Tumor necrosis factor signaling is implicated in intestinal mucosal injury of cancer cachexic mice

Jia Y, Tian W, Cui B

OncoTargets and Therapy 2012, 5:343-348

Published Date: 12 November 2012

Current migraine management – patient acceptability and future approaches

Arnaud Fumal, Jean Schoenen

Neuropsychiatric Disease and Treatment 2008, 4:1043-1057

Published Date: 5 December 2008

Progression to vascular dementia of patients with mild cognitive impairment: relevance of mild parkinsonian signs

Marco Mauri, Simona Corbetta, Cristina Pianezzola, Elena Ambrosoni, Giulio Riboldazzi, Giorgio Bono

Neuropsychiatric Disease and Treatment 2008, 4:1267-1271

Published Date: 5 December 2008

Mycophenolate mofetil for myasthenia gravis: a clear and present controversy

Chad Heatwole, Emma Ciafaloni

Neuropsychiatric Disease and Treatment 2008, 4:1203-1209

Published Date: 5 December 2008

Creation of virtual reality stimulus for a psychophysiological body balance measurement

Tero Alatalo, Martti Juhola, Veikko Surakka, Timo Tossavainen

Psychology Research and Behavior Management 2009, 2:13-22

Published Date: 23 November 2008