Back to Journals » Advances and Applications in Bioinformatics and Chemistry » Volume 14

An Overview of Current Uses and Future Opportunities for Computer-Assisted Design of Vaccines for Neglected Tropical Diseases

Authors Robleda-Castillo R, Ros-Lucas A, Martinez-Peinado N, Alonso-Padilla J

Received 20 October 2020

Accepted for publication 3 January 2021

Published 15 February 2021 Volume 2021:14 Pages 25—47


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Juan Fernandez-Recio

Raquel Robleda-Castillo, Albert Ros-Lucas, Nieves Martinez-Peinado, Julio Alonso-Padilla

Barcelona Institute for Global Health (ISGlobal), Hospital Clínic – University of Barcelona, Barcelona, 08036, Spain

Correspondence: Julio Alonso-Padilla Tel +34-932275400 (Ext. 4569)

Abstract: Neglected tropical diseases are infectious diseases that impose high morbidity and mortality rates over 1.5 billion people worldwide. Originally restricted to tropical and subtropical regions, changing climate conditions have increased their potential to emerge elsewhere. Control of their impact suffers from shortages like poor epidemiological surveillance or irregular drug distribution, and some NTDs still lack of appropriate diagnostics and/or efficient therapeutics. For these, availability of vaccines to prevent new infections, or the worsening of those already established, would mean a major breakthrough. However, only dengue and rabies count with approved vaccines at present. Herein, we review the state-of-the-art of vaccination strategies for NTDs, setting the focus on third generation vaccines and the concept of reverse vaccinology. Its capability to address pathogens´ biological complexity, likely contributing to save developmental costs is discussed. The use of computational tools is a fundamental aid to analyze increasingly large datasets aimed at designing vaccine candidates with the highest, possibly, opportunities to succeed. Ultimately, we identify and analyze those studies that took an in silico approach to find vaccine candidates, and experimentally assessed their immunogenicity and/or protection capabilities.

Keywords: neglected tropical diseases, vaccines, reverse vaccinology, immunoinformatics, epitopes

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]