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An evidence-based review of apixaban and its potential in the prevention of stroke in patients with atrial fibrillation

Authors Deedwania P, Huang GW

Received 22 March 2012

Accepted for publication 17 April 2012

Published 9 July 2012 Volume 2012:7 Pages 49—59


Review by Single-blind

Peer reviewer comments 2

Prakash Deedwania,1 Grace W Huang2

1Chief Cardiology Division, VACCHCS/UCSF, 2Division of Cardiology, UCSF Program, Fresno, CA, USA

Abstract: Atrial fibrillation (AF) is a common cardiac arrhythmia, especially in the elderly population. It is associated with cardioembolic complications, particularly strokes, resulting in severe functional deficit or death. AF patients are first stratified into low, intermediate, and high risk for thromboembolic events using the CHADS2 and CHA2DS2-VASc score systems. Depending on their risks, patients are treated with either therapeutic anticoagulation with warfarin or acetylsalicylic acid for stroke prevention. Although warfarin is the recommended therapy, it is underutilized clinically due to concern for narrow therapeutic window, drug-to-drug and drug-to-food interactions, and hemorrhagic complications. Newer anticoagulant agents such as dabigatran (a direct thrombin inhibitor) and rivaroxaban (a direct factor Xa inhibitor) have already been approved by US Food and Drug Administration for stroke prevention in patients with nonvalvular atrial fibrillation. Apixaban is the newest oral direct factor Xa inhibitor and it has been extensively studied in the AVERROES and ARISTOTLE trials. Apixaban demonstrated reduced incidence of primary outcome of stroke and bleeding events when compared with warfarin. Apixaban is currently being reviewed by the Food and Drug Administration as a stroke prophylactic agent. In addition, there are several other indirect factor Xa inhibitors and vitamin K antagonists under study presently. Results from these studies will provide us with information about possible alternatives to warfarin.

Keywords: atrial fibrillation, stroke prevention, apixaban

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