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Amniotic membrane allografts: development and clinical utility in ophthalmology

Authors Rizzuti A, Goldenberg A, Lazzaro D

Received 22 July 2014

Accepted for publication 19 August 2014

Published 9 December 2014 Volume 2014:1 Pages 67—72

DOI https://doi.org/10.2147/CWCMR.S50955

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Professor Marco Romanelli


Supplementary video 1: Pterygium surgery using amniotic membrane

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Allison Rizzuti,1,2 Adam Goldenberg,1 Douglas R Lazzaro1,2

1SUNY Downstate Medical Center, 2Kings County Hospital Center, Brooklyn, NY, USA


Abstract: Amniotic membrane, the innermost layer of the placenta, is a tissue that promotes epithelialization, while decreasing inflammation, neovascularization, and scarring. It is used in the surgical management of a wide variety of ophthalmic conditions where it functions as a graft or patch in ocular surface reconstruction. The development of new preservation techniques, as well as a sutureless amniotic membrane, has allowed for easier, in-office placement, without the disadvantages of an operating room procedure. The purpose of this review is to describe the historical development of amniotic membrane in ophthalmology and to describe its current clinical applications, particularly focusing on recent advances.

Keywords: ocular surface, cornea, stem cells, prokera, allograft, patch, transplantation

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