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Altered status of programmed death-ligand 1 after recurrence in resected lung adenocarcinoma patients

Authors Chen J, Li H, Pang RL, Huang J

Received 12 November 2016

Accepted for publication 23 January 2017

Published 6 April 2017 Volume 2017:10 Pages 2003—2007

DOI https://doi.org/10.2147/OTT.S127498

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 3

Editor who approved publication: Dr Tohru Yamada

Jun Chen, Hui Li, Ronglin Pang, Jia Huang

Department of Chemoradiotherapy, Yinzhou Hospital Affiliated to Ningbo University School of Medicine, Ningbo, People’s Republic of China

Purpose: Programmed death-ligand 1 (PD-L1) is found to be overexpressed in non-small cell lung cancer. The present study intended to evaluate the status of PD-L1 expression in patients with resection and recurrent lung adenocarcinoma.
Patients and methods: Matched resection and recurrent tumor samples were harvested from 65 lung adenocarcinoma patients. Immunohistochemistry was used to evaluate the status of PD-L1 expression. Kaplan–Meier method was used for survival analysis.
Results: A total of 65 patients of lung adenocarcinoma were enrolled. They underwent complete resection and had recurrence after adjuvant treatment. PD-L1 expression was identified in 43.1% (28/65) of resection samples vs 55.4% (36/65) of recurrent samples. Ten patients shifted from negative to positive, whereas another two samples showed the opposite. Patients with PD-L1 expression showed worse disease-free survival than the PD-L1-negative counterparts. The expression of PD-L1 in recurrent samples was a significant favorable factor for epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) (11.2 vs 8.2 months, P=0.030).
Conclusion: The status of PD-L1 expression may alter between resection and recurrent samples. Also, the status of PD-L1 expression after recurrence is a better prognostic factor for EGFR-TKIs.

Keywords:
programmed death-ligand 1, overexpression, lung adenocarcinoma, survival

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