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Altered serum levels of type I collagen turnover indicators accompanied by IL-6 and IL-8 release in stable COPD

Authors Zeng YY, Hu WP, Zuo YH, Wang XR, Zhang J

Received 19 September 2018

Accepted for publication 30 November 2018

Published 3 January 2019 Volume 2019:14 Pages 163—168

DOI https://doi.org/10.2147/COPD.S188139

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Professor Chunxue Bai


Ying-Ying Zeng,1 Wei-Ping Hu,1 Yi-Hui Zuo,1 Xiao-Ru Wang,2 Jing Zhang1

1Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; 2Department of Pulmonary Medicine, Dahua Hospital, Shanghai, China

Background: COPD, characterized by chronic inflammation and airway remodeling, has significant pathological alterations in composition and deposition of the extracellular matrix. The expression of procollagen 1 C-terminal peptide (PICP) and collagen type 1 C-terminal telopeptide (ICTP), two major by-products in the synthesis and degradation of collagen, was shown to be positively correlated with inflammatory mediator levels in previous studies.
Purpose: In this study, we investigated whether the serum concentrations of PICP and ICTP were associated with the inflammation level for patients with stable COPD.
Patients and methods: We collected serum samples from 25 control subjects and 20 patients with stable COPD from December 2011 to October 2012 in Shanghai Zhongshan Hospital and Shanghai Dahua Hospital. We determined concentrations of PICP, ICTP, C-reactive protein (CRP), IL-6, IL-8, and tumor necrosis factor (TNF)-α by using enzyme-linked immunosorbent assay methods.
Results: Demographic characteristics were comparable between the two groups. In patients with stable COPD, serum levels of CRP, IL-6, IL-8, and TNF-α were all elevated compared to control subjects, but only changes of IL-6 achieved statistical significance. Serum concentration of PICP was significantly elevated in patients with COPD, and level of ICTP was slightly decreased. Moreover, serum concentrations of PICP were positively correlated with the levels of both IL-6 and IL-8.
Conclusion: The increased levels of serum PICP in COPD might indicate the condition of airway remodeling, and IL-6 and/or IL-8 might play an important role in stimulating collagen synthesis.

Keywords: chronic obstructive pulmonary disease, COPD, procollagen type I C-terminal peptide, PICP, C-terminal telopeptide of type I collagen, ICTP, interleukin-6, IL-6, interleukin-8, IL-8

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