Back to Journals » Neuropsychiatric Disease and Treatment » Volume 12

Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study

Authors Huang X, Li S, Zhou F, Zhang Y, Zhong Y, Cai F, Shao Y, Zeng X

Received 31 January 2016

Accepted for publication 10 March 2016

Published 3 June 2016 Volume 2016:12 Pages 1303—1308

DOI https://doi.org/10.2147/NDT.S105478

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Xiang Mou

Peer reviewer comments 3

Editor who approved publication: Professor Wai Kwong Tang


Xin Huang,1,2,* Sheng-Hong Li,3,* Fu-Qing Zhou,3 Ying Zhang,1 Yu-Lin Zhong,1 Feng-Qin Cai,3 Yi Shao,1 Xian-Jun Zeng3

1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute and Oculopathy Research Centre, Nanchang, 2Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiujiang, 3Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi, People’s Republic of China

*These authors contributed equally to this work

Objective: To investigate the underlying regional homogeneity (ReHo) of brain-activity abnormalities in patients with comitant strabismus (CS) and their relationship with behavioral performance.
Methods: Twenty patients with CS (ten men and ten women) and 20 (ten men and ten women) age-, sex-, and education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess local features of spontaneous brain activities. Patients with CS were distinguished from HCs by receiver operating characteristic curve. Correlation analysis was performed to explore the relationship between the observed mean ReHo values of the different brain areas and behavioral performance.
Results: Compared to HCs, the patients with CS showed significantly increased ReHo values in the right inferior temporal cortex/fusiform gyrus/cerebellum anterior lobe, right lingual gyrus, and bilateral cingulate gyrus. We did not find any relationship between the observed mean ReHo values of the different brain areas and behavioral performance.
Conclusion: CS causes dysfunction in many brain regions, which may explain the fusion compensation in CS.

Keywords: comitant strabismus, regional homogeneity, functional magnetic resonance imaging, resting state

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]