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Alteration of spontaneous brain activity in COPD patients

Authors Zhang J, Chen J, Yu Q, Fan C, Zhang R, Lin J, Yang T, Fan M

Received 7 April 2016

Accepted for publication 30 May 2016

Published 28 July 2016 Volume 2016:11(1) Pages 1713—1719

DOI https://doi.org/10.2147/COPD.S110089

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell


Jiaxing Zhang,1 Ji Chen,1 Qian Yu,1 Cunxiu Fan,1 Ran Zhang,1 Jianzhong Lin,2 Tianhe Yang,2 Ming Fan3

1Department of Physiology, Medical College of Xiamen University, Xiangan, 2Magnetic Resonance Center, Department of Radiology, Zhongshan Hospital Xiamen University, Xiamen, Fujian, 3Department of Cognitive Sciences, Institute of Basic Medical Sciences, Beijing, People’s Republic of China

Background and objective: Airflow limitation in chronic obstructive pulmonary disease (COPD) results in a decrease in oxygen transport to the brain. The aim of the present study was to explore the alteration of spontaneous brain activity induced by hypoxia in patients with COPD.
Patients and methods: Twenty-five stable patients with COPD and 25 matching healthy volunteers were investigated. Amplitude of low-frequency fluctuation (ALFF) of blood oxygenation level-dependent signal at resting state in the brain was analyzed using functional magnetic resonance imaging.
Results: Whole-brain analysis using functional magnetic resonance imaging revealed significant decreases in ALFF in the bilateral posterior cingulate gyri and right lingual gyrus and an increase in ALFF in the left postcentral gyrus of patients with COPD. After controlling for SaO2, patients with COPD only showed an increase in ALFF in the left postcentral gyrus. Region of interest analysis showed a decrease in ALFF in the left precentral gyrus and an increase in ALFF in the left caudate nucleus of patients with COPD. In all subjects, ALFF in the bilateral posterior cingulate gyri and right lingual gyrus showed positive correlations with visual reproduction.
Conclusion: We demonstrated abnormal spontaneous brain activity of patients with COPD, which may have a pathophysiologic meaning.

Keywords: chronic obstructive pulmonary disease, hypoxia, low-frequency fluctuation, neuronal activity, resting-state fMRI

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