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Alogliptin in combination with metformin and pioglitazone for the treatment of type 2 diabetes mellitus

Authors Holland D, Neumiller J

Received 7 May 2014

Accepted for publication 30 May 2014

Published 3 July 2014 Volume 2014:7 Pages 277—288

DOI https://doi.org/10.2147/DMSO.S37648

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Daniel Q Holland, Joshua J Neumiller

Department of Pharmacotherapy, College of Pharmacy, Washington State University, Spokane, Washington, USA

Abstract: Alogliptin is a selective dipeptidyl peptidase-4 inhibitor recently marketed for once-daily administration in the treatment of type 2 diabetes mellitus (T2DM). Fixed-dose combinations of alogliptin with both metformin and pioglitazone are also commercially available, providing a measure of convenience in addition to an effective mode of delivering combination therapy to improve glycemic control. Alogliptin has been studied clinically as initial therapy in treatment-naïve patients with T2DM and as initial therapy or add-on in combination with other antidiabetic agents. Clinical trial data with alogliptin demonstrate clinical efficacy in terms of glycosylated hemoglobin A1c and fasting plasma glucose reductions when used both as monotherapy and as a component of two- or three-drug combination regimens for the treatment of T2DM. Extensive Phase II and Phase III clinical trial data support the use of alogliptin in combination with metformin and pioglitazone. Glycemic reduction with both combinations is similar to the sum of the respective monotherapies, with adverse event rates similar – or more moderate – than those observed with up-titration of monotherapy or the addition of other antihyperglycemic agents.

Keywords: antidiabetic, diabetes management, DPP-4 inhibitor, fixed-dose combination, incretin therapy

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