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Aldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis

Authors Xu YL, Hu YY, Li JW, Zhou L, Li L, Niu YM

Received 27 November 2018

Accepted for publication 3 March 2019

Published 23 April 2019 Volume 2019:15 Pages 1015—1029

DOI https://doi.org/10.2147/NDT.S196175

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 3

Editor who approved publication: Professor Jun Chen


Yue-Long Xu,1 Yuan-Yuan Hu,2 Ji-Wei Li,1 Lan Zhou,3 Li Li,1 Yu-Ming Niu2

1Department of Neurology, Linyi Central Hospital, Linyi 276400, Shandong Province, People’s Republic of China; 2Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, People’s Republic of China; 3Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, People’s Republic of China

Introduction: Recently, molecular epidemiological studies have suggested that aldehyde dehydrogenase 2 (ALDH2) rs671 G>A polymorphism may be a risk factor for ischemic stroke (IS). However, the results reported have not been consistent.
Methods: We conducted the meta-analysis to explore the precise association between ALDH2 rs671 G>A polymorphism and IS risk. Five online databases were searched and the relative studies were reviewed from inception to October 1, 2018. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated in each genetic model of the general and subgroup. Furthermore, the heterogeneity, accumulative analyses, sensitivity analyses and publication bias were calculated simultaneously.
Results: Overall, nine case-control studies involving 6,129 subjects were included in this meta-analysis. All studies were focused on the Chinese population and some significant associations were found between ALDH2 rs671 G>A polymorphism and IS risk (A vs G: OR=1.29, 95% CI=1.01–1.65, P=0.04, I2=78.2%; AA vs GG: OR=1.86, 95% CI=1.27–2.21, P<0.01, I2=11.3%; AA vs GG + GA: OR=1.67, 95% CI=1.27–2.19, P<0.01, I2=0%). Some significant and similar results were also observed in the subgroup analysis.
Conclusion: Our meta-analysis indicates that the ALDH2 rs671 G>A polymorphism may play an important role in the occurrence of IS by reducing the activity of ALDH2 and interfering with the metabolic processes involving acetaldehyde.

Keywords: aldehyde dehydrogenase 2, rs671, ischemic stroke, polymorphism, meta-analysis


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