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Aggressive natural killer cell leukemia: a case report

Authors Hu Y, Wang J

Received 4 March 2017

Accepted for publication 8 May 2017

Published 13 December 2017 Volume 2017:10 Pages 389—391

DOI https://doi.org/10.2147/IMCRJ.S136148

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Ronald Prineas

Ying Hu, Jingbo Wang

Department of Hematology, Aerospace Center Hospital, Beijing, People’s Republic of China

Abstract:
Aggressive natural killer (NK) cell leukemia is a rare hematological malignancy. It often presents with a rapidly declining clinical course and a poor prognosis with a median survival of a few months. We report the case of a 23-year-old man with high fever, enlarged lymph nodes, splenomegaly, cytopenia, liver dysfunctions, coagulation disorders and hemophagocytosis. Computed tomography scan showed right lung shadow. Lung involvement was considered. Histological examination of the lung was not performed because of low platelets and coagulation disorders. Bronchoscopic examination revealed positive Epstein-Barr virus in bronchoalveolar lavage fluid. Bone marrow and lymph node phenotype showed CD56+ CD3– NK cells type. He died of respiratory failure a week after diagnosis.

Keywords: hemophagocytosis, Epstein-Barr virus, CD56+ CD3– NK cells, aggressive natural killer cell leukemia

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