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Advances in the proteomic discovery of novel therapeutic targets in cancer

Authors Guo S, Zou J, Wang G

Received 30 July 2013

Accepted for publication 10 September 2013

Published 24 October 2013 Volume 2013:7 Pages 1259—1271

DOI https://doi.org/10.2147/DDDT.S52216

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Shanchun Guo,1 Jin Zou,2 Guangdi Wang3

1Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 2Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA, USA; 3Research Centers in Minority Institutions Cancer Research Program, Xavier University of Louisiana, New Orleans, LA, USA

Abstract: Proteomic approaches are continuing to make headways in cancer research by helping to elucidate complex signaling networks that underlie tumorigenesis and disease progression. This review describes recent advances made in the proteomic discovery of drug targets for therapeutic development. A variety of technical and methodological advances are overviewed with a critical assessment of challenges and potentials. A number of potential drug targets, such as baculoviral inhibitor of apoptosis protein repeat-containing protein 6, macrophage inhibitory cytokine 1, phosphoglycerate mutase 1, prohibitin 1, fascin, and pyruvate kinase isozyme 2 were identified in the proteomic analysis of drug-resistant cancer cells, drug action, and differential disease state tissues. Future directions for proteomics-based target identification and validation to be more translation efficient are also discussed.

Keywords: proteomics, cancer, therapeutic target, signaling network, tumorigenesis

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