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Advances in the design and development of oncolytic measles viruses

Authors Hutzen B, Raffel C, Studebaker A

Received 28 May 2015

Accepted for publication 14 July 2015

Published 27 August 2015 Volume 2015:4 Pages 109—118

DOI https://doi.org/10.2147/OV.S66078

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Malathi Krishnamurthy

Peer reviewer comments 3

Editor who approved publication: Dr Faris Farassati


Brian Hutzen,1 Corey Raffel,2 Adam W Studebaker1

1Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA; 2Department of Neurological Surgery and Pediatrics, University of California, San Francisco, San Francisco, CA, USA

Abstract: A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has rapidly emerged as a potentially useful anticancer modality. Derivatives of the Edmonston MV vaccine strain possess a remarkable safety record in humans. Promising results in preclinical animal models and evidence of biological activity in early phase trials contribute to the enthusiasm. Genetic modifications have enabled MV to evolve from a vaccine agent to a potential anticancer therapy. Specifically, alterations of the MV genome have led to improved tumor selectivity and delivery, therapeutic potency, and immune system modulation. In this article, we will review the advancements that have been made in the design and development of MV that have led to its use as a cancer therapy. In addition, we will discuss the evidence supporting its use, as well as the challenges associated with MV as a potential cancer therapeutic.

Keywords: virotherapy, measles virus, oncolytic therapy

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