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Advances in stent technologies and their effect on clinical efficacy and safety

Authors Nikam N, Steinberg T, Steinberg D

Received 26 November 2013

Accepted for publication 28 January 2014

Published 3 June 2014 Volume 2014:7 Pages 165—178

DOI https://doi.org/10.2147/MDER.S31869

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Navin Nikam, Toby B Steinberg, Daniel H Steinberg

Division of Cardiology, Medical University of South Carolina, Charleston, SC, USA

Abstract: The introduction of intracoronary stents represented a major advance in interventional cardiology. While bare metal stents set the benchmark for improved safety over angioplasty, intimal hyperplasia and subsequent restenosis were important limitations. First-generation drug-eluting stents demonstrated significant improvements in efficacy, but not necessarily safety, and further technologic developments have focused on optimizing both. Current advances and understanding in stent design continue to improve on these concepts. This review summarizes past and present technology with particular emphasis on the principles underlying the efficacy and safety of drug-eluting stents, and offers a glimpse into the next generations of stents aimed at treating symptomatic coronary artery disease.

Keywords: drug-eluting stents percutaneous coronary intervention, coronary artery disease, bioabsorbable polymers, bioabsorbable struts, polymer free

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