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Advances In Research Of Spreading Through Air Spaces And The Effects On The Prognosis Of Lung Cancer

Authors Cao D, Sha J, Cui R, Han S

Received 23 September 2019

Accepted for publication 2 November 2019

Published 15 November 2019 Volume 2019:11 Pages 9725—9732

DOI https://doi.org/10.2147/CMAR.S232187

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Aruna Narula

Peer reviewer comments 3

Editor who approved publication: Professor Bilikere Dwarakanath


Dandan Cao,1,2 Jun Sha,1,2 Rui Cui,1,2 Shuhua Han1

1Department of Pulmonary Medicine, Zhongda Hospital, School of Medicine, South-East University, Nanjing, Jiangsu, People’s Republic of China; 2Medicine Department of Southeast University, Nanjing, Jiangsu, People’s Republic of China

Correspondence: Shuhua Han
Department of Pulmonary Medicine, Zhongda Hospital, Ding Jia Qiao No. 87, Nanjing, Jiangsu 210009, People’s Republic of China
Email hanshuhua0922@126.com

Abstract: The concept of spread through air spaces (STAS) has been described as a new form of invasion in the lung in the 2015 WHO classification of Lung Tumors, namely invasion through alveolar spaces. STAS is a prognostic factor independent of growth pattern and tumor stage, and it is also an independent risk factor for unfavorable prognosis of stage I lung adenocarcinoma (ADC) and stage I lung squamous cell carcinoma (SCC). The pathological characteristics are different between ADC and SCC. STAS is not reported as routine, so setting a unified pathological reading standard, and hunting for STAS as a regular reading process is urgently advocated. We write this review to investigate the research progress of STAS and its effects on the prognosis of lung cancer.

Keywords: lung cancer, STAS, pathological characteristics, prognosis


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