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Advances in dosimetry and biological predictors of radiation-induced esophagitis

Authors Yu Y, Guan H, Dong Y, Xing L, Li X

Received 24 September 2015

Accepted for publication 2 December 2015

Published 28 January 2016 Volume 2016:9 Pages 597—603

DOI https://doi.org/10.2147/OTT.S97019

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Venktesh Shirure

Peer reviewer comments 3

Editor who approved publication: Professor Daniele Santini


Yang Yu,1 Hui Guan,1 Yuanli Dong,1 Ligang Xing,2 Xiaolin Li2

1School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, University of Jinan, Jinan, 2Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong Province, People’s Republic of China

Objective: To summarize the research progress about the dosimetry and biological predictors of radiation-induced esophagitis.
Methods: We performed a systematic literature review addressing radiation esophagitis in the treatment of lung cancer published between January 2009 and May 2015 in the PubMed full-text database index systems.
Results: Twenty-eight eligible documents were included in the final analysis. Many clinical factors were related to the risk of radiation esophagitis, such as elder patients, concurrent chemoradiotherapy, and the intense radiotherapy regimen (hyperfractionated radiotherapy or stereotactic body radiotherapy). The parameters including Dmax, Dmean, V20, V30, V50, and V55 may be valuable in predicting the occurrence of radiation esophagitis in patients receiving concurrent chemoradiotherapy. Genetic variants in inflammation-related genes are also associated with radiation-induced toxicity.
Conclusion: Dosimetry and biological factors of radiation-induced esophagitis provide clinical information to decrease its occurrence and grade during radiotherapy. More prospective studies are warranted to confirm their prediction efficacy.

Keywords: lung cancer, esophagitis, radiation injuries, predictors

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