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Advances and Prospects of Vasculogenic Mimicry in Glioma: A Potential New Therapeutic Target?

Authors Cai H, Liu W, Liu X, Li Z, Feng T, Xue Y, Liu Y

Received 31 January 2020

Accepted for publication 5 May 2020

Published 21 May 2020 Volume 2020:13 Pages 4473—4483

DOI https://doi.org/10.2147/OTT.S247855

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Leo Jen-Liang Su


Heng Cai,1– 3,* Wenjing Liu,4,* Xiaobai Liu,1– 3 Zhiqing Li,1– 3 Tianda Feng,1– 3 Yixue Xue,5 Yunhui Liu1– 3

1Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, People’s Republic of China; 2Liaoning Clinical Medical Research Center in Nervous System Disease, Shenyang 110004, People’s Republic of China; 3Key Laboratory of Neuro-Oncology in Liaoning Province, Shenyang 110004, People’s Republic of China; 4Department of Geriatrics, First Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 5Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang 110122, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Yunhui Liu Email sj_neurosurgery@126.com

Abstract: Vasculogenic mimicry (VM) is the formation of a “vessel-like” structure without endothelial cells. VM exists in vascular-dependent solid tumors and is a special blood supply source involved in the highly invasive tumor progression. VM is observed in a variety of human malignant tumors and is closely related to tumor proliferation, invasion, and recurrence. Here, we review the mechanism, related signaling pathways, and molecular regulation of VM in glioma and discuss current research problems and the potential future applications of VM in glioma treatment. This review may provide a new viewpoint for glioma therapy.

Keywords: glioma, vasculogenic mimicry, glioma stem cells, hypoxia, drug delivery systems, noncoding RNAs

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