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Advancements in nano-enabled therapeutics for neuroHIV management

Authors Kaushik A, Jayant RD, Nair M

Received 6 April 2016

Accepted for publication 16 June 2016

Published 1 September 2016 Volume 2016:11 Pages 4317—4325

DOI https://doi.org/10.2147/IJN.S109943

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Govarthanan Muthusamy

Peer reviewer comments 3

Editor who approved publication: Professor Carlos Rinaldi


Ajeet Kaushik, Rahul Dev Jayant, Madhavan Nair

Center for Personalized NanoMedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA

Abstract:
This viewpoint is a global call to promote fundamental and applied research aiming toward designing smart nanocarriers of desired properties, novel noninvasive strategies to open the blood–brain barrier (BBB), delivery/release of single/multiple therapeutic agents across the BBB to eradicate neurohuman immunodeficiency virus (HIV), strategies for on-demand site-specific release of antiretroviral therapy, developing novel nanoformulations capable to recognize and eradicate latently infected HIV reservoirs, and developing novel smart analytical diagnostic tools to detect and monitor HIV infection. Thus, investigation of novel nanoformulations, methodologies for site-specific delivery/release, analytical methods, and diagnostic tools would be of high significance to eradicate and monitor neuroacquired immunodeficiency syndrome. Overall, these developments will certainly help to develop personalized nanomedicines to cure HIV and to develop smart HIV-monitoring analytical systems for disease management.

Keywords: nanotherapeutics, personalized nanomedicine, smart monitoring analytical systems, HIV disease management

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