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Advanced Lung Cancer Inflammation Index is a Prognostic Factor of Patients with Small-Cell Lung Cancer Following Surgical Resection

Authors Hu Z, Wu W, Zhang X, Li P, Zhang H, Wang H, Xue W, Chen Z, Zhao Q, Duan G

Received 8 December 2020

Accepted for publication 31 January 2021

Published 26 February 2021 Volume 2021:13 Pages 2047—2055

DOI https://doi.org/10.2147/CMAR.S295952

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Ahmet Emre Eşkazan


Zhonghui Hu,1,2,* Wenbo Wu,1,3,* Xiaopeng Zhang,1 Ping Li,4,* Hua Zhang,1 Huien Wang,1 Wenfei Xue,1 Zhiguo Chen,5 Qingtao Zhao,1 Guochen Duan1,5

1Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 2Graduate School, Hebei Medical University, Shijiazhuang, People’s Republic of China; 3Graduate School, Hebei North University, Zhangjiakou, People’s Republic of China; 4Department of Thoracic Surgery, Zigong First People’s Hospital, Zigong, People’s Republic of China; 5Department of Thoracic Surgery, Hebei Children’s Hospital, Shijiazhuang, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Guochen Duan
Hebei Children’s Hospital, No. 133 Jianhua South Street, Yuhua District, Shijiazhuang, 050000, People’s Republic of China
Tel +86 311 13380703
Email [email protected]
Qingtao Zhao
Hebei General Hospital, No. 384 Heping West Road, Xinhua District, Shijiazhuang, 050000, People’s Republic of China
Tel +86 311 85988756
Email [email protected]

Purpose: Advanced lung cancer inflammation index (ALI) has been shown to predict overall survival (OS) in advanced non small-cell lung cancer (NSCLC), small-cell lung cancer (SCLC) and operable NSCLC. However, there were no studies of the correlation between ALI and operable SCLC. Therefore, this study is aimed to explore the relationship between ALI and the prognosis of operable SCLC.
Patients and Methods: A total of 48 patients with SCLC who underwent surgery at Hebei General Hospital and Zigong First People’s Hospital were screened between 2016 and 2020. ALI was calculated as follows: body mass index (BMI, kg/m2)×serum albumin (ALB, g/dL)/neutrophil to lymphocyte ratio (NLR). Receiver operating characteristic (ROC) curve was used to determine the optimal cutoff value of ALI. Patients were divided into two groups according to the cutoff point of ALI: low ALI group with ALI< 48.2 and high ALI group with ALI≥ 48.2. Kaplan-Meier and Cox regression analysis were performed to assess the potential prognostic factors associated with OS.
Results: The optimal cutoff value of ALI was determined as 48.2. The low ALI group displayed more adverse clinical characteristics and poorer survival rates. Multivariate analysis revealed that ALI and Charlson comorbidity index (CCI) were significantly correlated with OS.
Conclusion: Low ALI was correlated with poor prognosis in patients with SCLC who underwent surgery. Preoperative ALI might serve as a potential prognostic marker for patients with operable SCLC.

Keywords: ALI, SCLC, surgery, prognosis

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