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Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy

Authors Soiberman U, Levy R, Leibovitch I

Received 2 June 2013

Accepted for publication 5 July 2013

Published 26 August 2013 Volume 2013:7 Pages 1723—1726

DOI https://doi.org/10.2147/OPTH.S49350

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Uri Soiberman,1,2 Ran Levy,1,2 Igal Leibovitch1,2

1Department of Ophthalmology, Tel Aviv Medical Center, 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Background: "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA.
Aim: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls.
Methods: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay.
Results: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20).
Conclusion: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.

Keywords: Graves' disease, Graves' orbitopathy, ELISA

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