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Adherence to Anti-Tuberculosis Treatment Among Pediatric Patients at Nekemte Specialized Hospital, Western Ethiopia

Authors Fekadu G, Bekele F, Bekele K, Girma T, Mosisa G, Gebre M, Alemu T, Tekle T, Gamachu B, Diriba A

Received 29 April 2020

Accepted for publication 26 June 2020

Published 24 July 2020 Volume 2020:14 Pages 1259—1265

DOI https://doi.org/10.2147/PPA.S258292

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Johnny Chen


Ginenus Fekadu,1 Firomsa Bekele,2 Kumera Bekele,3 Tsiyon Girma,4 Getu Mosisa,5 Mohammed Gebre,1 Tamirat Alemu,1 Tesfa Tekle,1 Busha Gamachu,1 Amenu Diriba6

1Department of Pharmacy, Institute of Health Science, Wollega University, Nekemte, Ethiopia; 2Department of Pharmacy, College of Health Science, Mettu University, Mettu, Ethiopia; 3Department of Nursing, College of Health Science, Selale University, Fiche, Ethiopia; 4Department of Pharmacy, Wollega University Referral Hospital, Nekemte, Ethiopia; 5Department of Nursing, Institute of Health Science, Wollega University, Nekemte, Ethiopia; 6Department of Obstetrics and Gynecology, School of Medicine, Institute of Health Science, Wollega University, Nekemte, Ethiopia

Correspondence: Firomsa Bekele
Department of Pharmacy, College of Health Science, Mettu University, Mettu, Ethiopia
Tel +251-919536460
Email firomsabekele21@gmail.com

Background: Non-adherence to tuberculosis treatment is the most challenging and hindering factor for successful tuberculosis therapy. The long duration of tuberculosis treatment and the undesirable effects of anti-tuberculosis drugs result in non-adherence to treatment among pediatric patients. Hence, this study was aimed to evaluate pediatrics adherence status among tuberculosis pediatric patients on anti-tuberculosis treatment at Nekemte Specialized Hospital.
Methods: A health facility-based cross-sectional study design was used to recruit pediatric TB patients who were receiving their treatment between February 15 and March 15, 2019. Adherence to tuberculosis therapy was evaluated using data obtained from face-to-face interviews of their respective caregivers. The collected data were entered into EPI-manager 4.0.2 software and analyzed using SPSS version 24. Logistic regression was used to analyze the variables and variables with p-value < 0.05 had a statistically significant association with the adherence to anti TB treatment.
Results: Among 202 participants involved in the study, 120 (59.4%) of them were males and 119 (58.9%) were in the age category of 11– 15 years. A total of 166 (82.2%) of the patients had extra-pulmonary tuberculosis and 174 (86.1%) of them were in the intensive phase. Of the pediatric tuberculosis patients, 48 (73.3%) of them have adhered to the treatment regimen. Female gender [AOR: 3.3, 95% CI: 1.52– 7.2], younger age (0– 5 years) [AOR: 5.96 95% CI: 1.81– 19.6], living in urban area [AOR: 3.73, 95% CI: 1.67– 8.36], and patients who did not experience side effect [AOR: 2.87, 95% CI: 1.41– 5.81] were predictors of good adherence to tuberculosis treatment up on multivariable logistic regression analysis.
Conclusion: The level of adherence observed in our study area was low. Age, sex, residence, and side effect experience showed an association with tuberculosis treatment adherence. Therefore, health care providers should educate all patients with tuberculosis before the initiation of anti-tuberculosis treatment.

Keywords: adherence, pediatrics, tuberculosis, treatment, Ethiopia

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