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Adherence and rehospitalizations in patients with schizophrenia: evidence from Japanese claims data

Authors Kuwabara H, Saito Y, Mahlich J

Received 27 January 2015

Accepted for publication 6 March 2015

Published 1 April 2015 Volume 2015:11 Pages 935—940


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Professor Wai Kwong Tang

Hiroyo Kuwabara,1 Yoshimichi Saito,1 Jörg Mahlich1,2

1Health Economics, Janssen KK, Tokyo, Japan; 2Düsseldorf Institute for Competition Economics, University of Düsseldorf, Düsseldorf, Germany

Background: The aim of this study is to analyze if there is a relationship between adherence to antipsychotic medication and rehospitalization for patients diagnosed with schizophrenia in Japan.
Methods: Based on Japanese claims data, we constructed three patient groups based on their medication possession ratio (MPR). Controlling for potential confounders, a Cox proportional hazard model was employed to assess if medication adherence affects the risk of rehospitalization.
Results: Patients with good adherence (MPRs from 0.8–1.1) had the lowest rates of admission. Both poor adherence (MPRs <0.8) and overadherence (MPRs >1.1) were associated with a significant higher risk of rehospitalization with hazard ratios of 4.7 and 2.0, respectively.
Conclusion: The results of this study support the notion that good adherence to antipsychotic medication reduces the risk of rehospitalization of schizophrenia patients. Appropriate measures should be taken to improve adherence of schizophrenia patients.

Keywords: adherence, hospitalizations, schizophrenia, Japan, claims data

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