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Adenosine A2a receptor agonists as regulators of inflammation: pharmacology and therapeutic opportunities

Authors Morello S, Sorrentino R, Pinto A

Published 5 August 2009 Volume 2009:2 Pages 11—17

DOI https://doi.org/10.2147/JRLCR.S4710

Review by Single-blind

Peer reviewer comments 3


Silvana Morello, Rosalinda Sorrentino, Aldo Pinto

Department of Pharmaceutical Sciences, Biomedical Section, University of Salerno, Via Ponte don Melillo, 84084 Fisciano, Salerno, Italy

Abstract: A2a receptor (A2aR) plays an important role in the regulation of inflammatory and immune responses. The activation of PKA-dependent and/or -independent pathways are responsible for the downmodulation of inflammatory networks and tissue injury. Based on promising recent studies, selective A2aR agonists are under clinical investigations for a wide range of disorders, such as ischemia-reperfusion injury, chronic inflammation, and infectious diseases. Nevertheless, further studies are required to improve our understanding in the ability of A2a receptor agonists to reduce tissue damage during inflammation. Characterization of A2aR-induced signaling pathways will be useful for the development of novel therapeutic strategies in inflammatory/immune diseases.

Keywords: adenosine, A2a receptor, A2a receptor agonists, inflammation

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