Addition Of D-Sorbitol Improves The Usability Of Ophthalmic Viscosurgical Devices
Received 7 June 2019
Accepted for publication 4 September 2019
Published 23 September 2019 Volume 2019:13 Pages 1877—1885
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Ippei Watanabe,1 Mayumi Nagata,2 Hiroyuki Matsushima2
1Medical Science Liaison Unit, Seikagaku Corporation, Tokyo, Japan; 2Department of Ophthalmology, Dokkyo Medical University, Tochigi, Japan
Correspondence: Ippei Watanabe
Medical Science Liaison Unit, Seikagaku Corp., 6-1, Marunouchi 1-chome, Chiyoda-ku, Tokyo 100-0005, Japan
Tel +81 3 352208595
Fax +81 3 352208975
Purpose: To evaluate the effects of D-sorbitol addition on changes in the extrusion force of ophthalmic viscosurgical devices (OVDs).
Methods: OVD formulations; the mixtures of 3% hyaluronic acid (HA) and 4% chondroitin sulfate (CS) containing 0%, 0.5%, or 1.0% D-sorbitol were prepared. Each prefilled syringe of OVD was stored at room temperature for 0, 15, 30, 60, or 120 mins after a small amount of viscoelastic agent was discharged from the needle. The extrusion force values (kgf) of these OVDs when reused after storage were measured with a texture analyzer. Moreover, 10 healthy adults (5 men and 5 women) used a pinch sensor to measure the extrusion force values for the HA/CS combination without D-sorbitol which was stored in the above manner, and used a 4-step scale to score the usability of OVD.
Results: For the HA/CS combination without D-sorbitol, the extrusion force value was increased from its initial value (storage duration, 0 min) as storage duration increased. However, for the HA/CS combination containing 0.5% or 1.0% D-sorbitol, this value remained almost unchanged over time. Likewise, the pinch sensor-determined extrusion force values of HA/CS combination without D-sorbitol increased, depending on storage duration.
Conclusion: The addition of D-sorbitol to viscoelastic agent may suppress the needle clogging that occurs with OVD storage, and may improve the usability of OVDs during surgery.
Keywords: ophthalmic viscosurgical device, extrusion force, cataract surgery, vitreous surgery
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