Addition Of D-Sorbitol Improves The Usability Of Ophthalmic Viscosurgical Devices
Received 7 June 2019
Accepted for publication 4 September 2019
Published 23 September 2019 Volume 2019:13 Pages 1877—1885
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Ippei Watanabe,1 Mayumi Nagata,2 Hiroyuki Matsushima2
1Medical Science Liaison Unit, Seikagaku Corporation, Tokyo, Japan; 2Department of Ophthalmology, Dokkyo Medical University, Tochigi, Japan
Correspondence: Ippei Watanabe
Medical Science Liaison Unit, Seikagaku Corp., 6-1, Marunouchi 1-chome, Chiyoda-ku, Tokyo 100-0005, Japan
Tel +81 3 352208595
Fax +81 3 352208975
Purpose: To evaluate the effects of D-sorbitol addition on changes in the extrusion force of ophthalmic viscosurgical devices (OVDs).
Methods: OVD formulations; the mixtures of 3% hyaluronic acid (HA) and 4% chondroitin sulfate (CS) containing 0%, 0.5%, or 1.0% D-sorbitol were prepared. Each prefilled syringe of OVD was stored at room temperature for 0, 15, 30, 60, or 120 mins after a small amount of viscoelastic agent was discharged from the needle. The extrusion force values (kgf) of these OVDs when reused after storage were measured with a texture analyzer. Moreover, 10 healthy adults (5 men and 5 women) used a pinch sensor to measure the extrusion force values for the HA/CS combination without D-sorbitol which was stored in the above manner, and used a 4-step scale to score the usability of OVD.
Results: For the HA/CS combination without D-sorbitol, the extrusion force value was increased from its initial value (storage duration, 0 min) as storage duration increased. However, for the HA/CS combination containing 0.5% or 1.0% D-sorbitol, this value remained almost unchanged over time. Likewise, the pinch sensor-determined extrusion force values of HA/CS combination without D-sorbitol increased, depending on storage duration.
Conclusion: The addition of D-sorbitol to viscoelastic agent may suppress the needle clogging that occurs with OVD storage, and may improve the usability of OVDs during surgery.
Keywords: ophthalmic viscosurgical device, extrusion force, cataract surgery, vitreous surgery
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]