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Acute bilateral angle closure glaucoma induced by methazolamide

Authors Aref A, Sayyad F, Ayres B, Lee R

Received 13 December 2012

Accepted for publication 9 January 2013

Published 11 February 2013 Volume 2013:7 Pages 279—282

DOI https://doi.org/10.2147/OPTH.S41540

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Ahmad A Aref,1,2 Fouad E Sayyad,2 Bernadete Ayres,2 Richard K Lee2

1Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 2Illinois Eye and Ear Infirmary, University of Illinois at Chicago School of Medicine, Chicago, IL, USA

Purpose: To report a case of bilateral acute myopia and angle closure glaucoma after ingestion of methazolamide.
Methods: An interventional case report of a 70-year-old male who developed bilateral, acute myopia and angle closure glaucoma after ingesting methazolamide tablets for the treatment of normal tension glaucoma.
Results: Bilateral anterior chamber shallowing associated with ciliary body edema, supraciliary effusions, and shallow posterior choroidal effusions were documented with slit-lamp photography and high-frequency ultrasonography. Near complete resolution of these signs after discontinuation of methazolamide were also documented.
Conclusion: Methazolamide may be associated with secondary myopia and angle closure glaucoma. Discontinuation of methazolamide leads to resolution of this process, as documented by slit-lamp photography and high-frequency ultrasonography.

Keywords: glaucoma, glaucoma pharmacology, angle closure glaucoma

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