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Acute and chronic effects of resistance exercise on blood pressure in elderly women and the possible influence of ACE I/D polymorphism

Authors Mota MR, Oliveira RJD, Terra DF, Pardono E, Dutra MT, Almeida JAD, Silva FM

Received 23 November 2012

Accepted for publication 16 March 2013

Published 12 July 2013 Volume 2013:6 Pages 581—587

DOI https://doi.org/10.2147/IJGM.S40628

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Márcio Rabelo Mota,1,3 Ricardo Jacó Oliveira,2 Denize Faria Terra,3 Emerson Pardono,4 Maurílio Tiradentes Dutra,2 Jeeser Alves de Almeida,3 Francisco Martins Silva3

1University Center of Brasília (UniCeub), Brasília, Brazil; 2University of Brasília (UnB), Brasília, Brazil; 3Catholic University of Brasília (UCB), Brasília, Brazil; 4Federal University of Sergipe (UFS), São Cristóvão, Brazil

Abstract: This study investigated the chronic effect of blood pressure (BP) and post-exercise hypotension (PEH) during resistance training (RT) and its relation with the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in hypertensive elderly women. Participants were divided into two groups: an experimental group (EG) with exercise and a control group (CG) without exercise. The EG performed one adaptation month and one repetition maximum load (1RM) test at the end of this period. After the first month, the EG conducted a three-month program of RT at 60%, 70%, and 80% of 1RM, respectively, for each month. The CG was evaluated at the end of each month. Systolic (SBP) and diastolic (DBP) blood pressure (Microlife BP 3AC1-1) were measured, with the subject in a seated position, during an acute session for both GE and CG as follows: every 5 minutes for 20 minutes at pre-exercise rest, immediately after the resistance exercise and control, and every 15 minutes during 1 hour of recovery after exercise and CG. Analysis of covariance showed reduction in SBP and DBP (P ≤ 0.05) rest values after the RT program. PEH was observed only for the EG in acute sessions, for SBP after the second and third months (P ≤ 0.05), and for DBP after the second and fourth months (P ≤ 0.05). No significant differences in main effects and interaction effects between blood pressure and ACE I/D were observed. The occurrence of chronic reduction of blood pressure and PEH through EG may have a protective effect on the cardiovascular system with no ACE I/D polymorphism influence for this population.

Keywords: post-exercise hypotension, resistance exercise, angiotensin-converting enzyme, genetics, polymorphism

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