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Activity of siderophores against drug-resistant Gram-positive and Gram-negative bacteria

Authors Gokarn K, Pal RB

Received 8 August 2017

Accepted for publication 3 October 2017

Published 9 January 2018 Volume 2018:11 Pages 61—75


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Sahil Khanna

Karuna Gokarn,1,2 Ramprasad B Pal1

1Department of Microbiology, Sir Hurkisondas Nurrotumdas Medical Research Society, 2Caius Research Laboratory, St Xavier’s College, Mumbai, India

Abstract: Infections by drug-resistant bacteria are life-threatening. As iron is a vital element for the growth of bacteria, iron-chelating agents (siderophores) can be used to arrest their multiplication. Exogenous siderophores – exochelin-MS and deferoxamine-B – were evaluated for their inhibitory activity against methicillin-resistant Staphylococcus aureus and metallo-β-lactamase producers – Pseudomonas aeruginosa and Acinetobacter baumannii – by disc diffusion, micro-broth dilution, and turbidimetric growth assays. The drug-resistant isolates were inhibited by the synergistic activity of siderophores and antibiotics. Minimum inhibitory concentration of exochelin-MS+ampicillin for different isolates was between 0.05 and 0.5 mg/mL. Minimum inhibitory concentration of deferoxamine-B+ampicillin was 1.0 mg/mL and greater. Iron-chelation therapy could provide a complementary approach to overcome drug resistance in pathogenic bacteria.

Keywords: iron-chelation, xenosiderophores, exochelin MS, deferoxamine B

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