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Acromegaly: a challenging condition to diagnose

Authors AlDallal S

Received 29 March 2018

Accepted for publication 12 June 2018

Published 24 August 2018 Volume 2018:11 Pages 337—343

DOI https://doi.org/10.2147/IJGM.S169611

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Salma AlDallal

Haematology & Blood Bank Department, Amiri Hospital, Kuwait Ministry of Health, Sharq, Kuwait

Abstract: Acromegaly is an uncommon, chronic disease, characterized by hypersecretion of a pituitary growth hormone by somatotroph adenomas, along with increased levels of insulin-like growth factor-1. Although acromegaly presents a wide array of clinical manifestations, the salient symptoms include acral and soft tissue enlargement, joint pain, heart and respiratory failure, diabetes mellitus, and hypertension, leading to increased morbidity and mortality. Hence, early diagnosis of the disease is critical to enhance life expectancy and quality of life. New approaches are being developed for diagnosis and surveillance (both screening and follow-up), including sensitive biochemical assays and the use of MRI to visualize extremely small tumors, and are helpful in the early diagnosis of acromegaly, subsequent treatment, and disease control. This ­mini-review summarizes the most common and effective tools used in the diagnosis of acromegaly.

Keywords: pituitary growth hormone, pituitary gland, diabetes mellitus, biochemical assays, acromegaly

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