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Acquired hemophilia A: emerging treatment options

Authors Janbain M, Leissinger CA, Kruse-Jarres R

Received 11 November 2014

Accepted for publication 2 March 2015

Published 8 May 2015 Volume 2015:6 Pages 143—150

DOI https://doi.org/10.2147/JBM.S77332

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Dr Martin Bluth

Maissaa Janbain,1 Cindy A Leissinger,1 Rebecca Kruse-Jarres2

1Louisiana Center for Bleeding and Clotting Disorders, Tulane University Medical Center, New Orleans, LA, USA; 2Washington Center for Bleeding Disorders, Blood Works NW, Seattle, WA, USA

Abstract: Acquired hemophilia A is a rare autoimmune disorder caused by an autoantibody (inhibitor) to factor VIII (FVIII) that interferes with its coagulant function and predisposes to severe, potentially life-threatening hemorrhage. Disease management focuses on controlling bleeding, primarily with the use of bypassing therapy and recombinant porcine FVIII, and permanently eradicating the autoantibody using various immunosuppressants. Treatment challenges include delayed diagnosis, difficulty achieving hemostasis and durable remissions, and complications associated with the use of hemostatic and immunosuppressive therapy in a primarily older patient population.

Keywords: autoantibodies, factor VIII, hemostasis, inhibitors, inhibitor eradication

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