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Acquired Factor XIII Deficiency Inducing Recurrent and Fatal Bleeding, Description of a Case

Authors Di Micco P, Gussoni G, Pieralli F, Campanini M, Dentali F, Fontanella A

Received 23 September 2019

Accepted for publication 3 December 2019

Published 30 January 2020 Volume 2020:11 Pages 43—45

DOI https://doi.org/10.2147/JBM.S232115

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Martin H. Bluth


Pierpaolo Di Micco,1 Gualberto Gussoni,2 Filippo Pieralli,3 Mauro Campanini,4 Francesco Dentali,5 Andrea Fontanella1

1Department of Internal Medicine and Emergency Room, Fatebenefratelli Hospital of Naples, Naples, Italy; 2Centro Studi FADOI, Milan, Italy; 3Department of Medicine, Hospital Careggi, Florence, Italy; 4Department of Internal Medicine, Ospedale Maggiore, Novara, Italy; 5Department of Internal Medicine, University of Insubria, Varese, Italy

Correspondence: Pierpaolo Di Micco
Department of Internal Medicine and Emergency Room, Fatebenefratelli Hospital of Naples, Naples, Italy
Email pdimicco@libero.it

Abstract: Factor XIII deficiency may be inherited or acquired. Inherited deficiency is associated with signs and symptoms of minor bleeding from a young age, and possible major bleeding complications, in particular during pregnancy. On the other hand, acquired factor XIII deficiency is usually associated with severe symptoms of major bleeding, in particular during surgery. In this paper, we report an interesting case of recurrent major bleeding with subsequent fatal bleeding in an adult man diagnosed with acquired factor XIII deficiency.

Keywords: factor XIII deficiency, acquired haemophilia, blood disorders, bleeding, fatal bleeding

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