Back to Journals » International Medical Case Reports Journal » Volume 7

Acquired factor V inhibitor in a patient with mantle cell lymphoma presenting with hematuria followed by thrombosis: a case report

Authors AlJohani N, Matthews J

Received 15 December 2013

Accepted for publication 15 January 2014

Published 24 February 2014 Volume 2014:7 Pages 27—30


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Naif I AlJohani,1,2 John H Matthews2

1King Faisal specialist hospital and research centre, Saudi Arabia; 2Division of Hematology, Department of Internal Medicine, Queen's University, Kingston, Ontario, Canada

Abstract: Acquired factor V inhibitor is a rare hemostatic disorder that presents with hemorrhagic manifestations in the vast majority of patients. Factor V inhibitor may develop through a variety of mechanisms involving development of alloantibodies or autoantibodies specific to Factor V. Autoantibodies, in particular, have been reported in a number of conditions. In this report, we describe a case of acquired factor V inhibitor in a patient with mantle cell lymphoma who presented with hematuria. Seven weeks after diagnosis and successful management, the patient developed deep vein thrombosis in the right lower extremity. The patient's factor V levels were normalized, and the inhibitor was successfully eradicated using corticosteroids. Here, we discuss this rare disorder, its unusual manifestation, and provide a mini-review of the current literature regarding factor V inhibitors.

Keywords: acquired factor V inhibitor, blood coagulation disorders, factor V deficiency, acquired bleeding disorders

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]