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Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers

Authors Le NHA, Phan HV, Yu J, Chan HK, Neild A, Alan T

Received 13 October 2017

Accepted for publication 9 December 2017

Published 8 March 2018 Volume 2018:13 Pages 1353—1359

DOI https://doi.org/10.2147/IJN.S153805

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Govarthanan Muthusamy

Peer reviewer comments 2

Editor who approved publication: Dr Thomas J. Webster


Nguyen Hoai An Le,1 Hoang Van Phan,1 Jiaqi Yu,2 Hak-Kim Chan,2 Adrian Neild,1 Tuncay Alan1

1Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, 2The Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia

Background: This article presents an acoustically enhanced microfluidic mixer to generate highly uniform and ultra-fine nanoparticles, offering significant advantages over conventional liquid antisolvent techniques.
Methods: The method employed a 3D microfluidic geometry whereby two different phases – solvent and antisolvent – were introduced at either side of a 1 µm thick resonating membrane, which contained a through-hole. The vibration of the membrane rapidly and efficiently mixed the two phases, at the location of the hole, leading to the formation of nanoparticles.
Results: The versatility of the device was demonstrated by synthesizing budesonide (a common asthma drug) with a mean diameter of 135.7 nm and a polydispersity index of 0.044.
Conclusion: The method offers a 40-fold reduction in the size of synthesized particles combined with a substantial improvement in uniformity, achieved without the need of stabilizers.

Keywords: microfluidics, nanodrugs, budesonide, liquid antisolvent method

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