Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers
Authors Le NHA, Phan HV, Yu J, Chan HK, Neild A, Alan T
Received 13 October 2017
Accepted for publication 9 December 2017
Published 8 March 2018 Volume 2018:13 Pages 1353—1359
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Thomas Webster
Nguyen Hoai An Le,1 Hoang Van Phan,1 Jiaqi Yu,2 Hak-Kim Chan,2 Adrian Neild,1 Tuncay Alan1
1Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, 2The Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
Background: This article presents an acoustically enhanced microfluidic mixer to generate highly uniform and ultra-fine nanoparticles, offering significant advantages over conventional liquid antisolvent techniques.
Methods: The method employed a 3D microfluidic geometry whereby two different phases – solvent and antisolvent – were introduced at either side of a 1 µm thick resonating membrane, which contained a through-hole. The vibration of the membrane rapidly and efficiently mixed the two phases, at the location of the hole, leading to the formation of nanoparticles.
Results: The versatility of the device was demonstrated by synthesizing budesonide (a common asthma drug) with a mean diameter of 135.7 nm and a polydispersity index of 0.044.
Conclusion: The method offers a 40-fold reduction in the size of synthesized particles combined with a substantial improvement in uniformity, achieved without the need of stabilizers.
Keywords: microfluidics, nanodrugs, budesonide, liquid antisolvent method
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