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ACEIs and ARBs and Their Correlation with COVID-19: A Review

Authors Yehualashet AS, Belachew TF

Received 28 May 2020

Accepted for publication 7 August 2020

Published 16 September 2020 Volume 2020:13 Pages 3217—3224

DOI https://doi.org/10.2147/IDR.S264882

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Suresh Antony


Awgichew Shewasinad Yehualashet,1 Teshome Fentik Belachew2

1Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia; 2Department of Pharmacy, Debre Birhan Health Science College, Debre Birhan, Ethiopia

Correspondence: Awgichew Shewasinad Yehualashet Pharmacology and Toxicology Unit, Department of Pharmacy
College of Health Sciences, Debre Berhan University, PO BOX. 445, Debre Berhan, Ethiopia
Tel +251 935450290
Email awgshewa@gmail.com

Abstract: Although some animal studies suggested that the use of ACEIs/ARBs could contribute for the prevention and treatment of the effects of the COVID-19 infection, there are also contradictory scenarios indicating that their use may exacerbate the deleterious conditions of the infection. As a result of the paradoxical issue of using ACEIs/ARBs during COVID-19, it is still an area requiring extended investigation to prove. Additionally, a trial evidence of their efficacy and the possible benefit risk analysis of these conventional drugs during COVID-19 in connection with other comorbidities like hypertension, heart failure, and renal disease associated with diabetes should also be addressed.

Keywords: coronavirus, COVID-19, ACEIs, ARBs

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