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Absence of the toll-like receptor 4 gene polymorphisms Asp299Gly and Thr399Ile in Singaporean Chinese

Authors Xiao Hui Liang, Wai Cheung, Chew Kiat Heng, De-Yun Wang

Published 15 October 2005 Volume 2005:1(3) Pages 243—246

Xiao Hui Liang1, Wai Cheung3, Chew Kiat Heng2, De-Yun Wang1

1Departments of Otolaryngology and 2Pediatrics, National University of Singapore, Singapore; 3Department of Pediatrics, Oregon Health and Science University, OR, USA

Abstract: Toll-like receptor 4 (TLR4) is the transuding subunit of lipopolysaccharide receptor and an important intracellular signal pathway of the innate immune response. Published data about the relationship between TLR4 mutations and atopy/asthma are not consistent. This study was performed to detect two commonly reported Asp299Gly and Thr399Ile polymorphisms in TLR4 gene in Singaporean Chinese and their possible association with atopy-related phenotypes. A total of 117 unrelated Singapore residents were randomly selected for this study. Among them, atopy was evident in 66 subjects while 61 had allergic rhinitis. Twenty-one patients had concomitant asthma and 17 were atopic. In all subjects, neither the Asp299Gly nor Thr399Ile polymorphism was found by DNA sequencing. This discrepant result could be due to the ethnic variation of allelic distribution in TLR4 gene. Although it is still debatable whether there is any role of TLR4 polymorphisms on atopy-related phenotypes, one needs to develop an appropriate model to investigate the interactions between genetic variations and environmental factors that contribute to the complex traits in allergic diseases.

Keywords: TLR4 polymorphisms, Singaporean Chinese, atopy

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