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Aberrant Executive Control and Auditory Networks in Recent-Onset Schizophrenia

Authors Joo SW, Yoon W, Jo YT, Kim H, Kim Y, Lee J

Received 16 March 2020

Accepted for publication 27 May 2020

Published 22 June 2020 Volume 2020:16 Pages 1561—1570

DOI https://doi.org/10.2147/NDT.S254208

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Taro Kishi


Sung Woo Joo,1 Woon Yoon,2 Young Tak Jo,2 Harin Kim,2 Yangsik Kim,2 Jungsun Lee2

1Medical Corps, Republic of Korea Navy 1st Fleet, Donghae, Republic of Korea; 2Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Correspondence: Jungsun Lee
Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul 05505, Republic of Korea
Tel +82-2-3010-3422
Fax +82-2-485-8381
Email js_lee@amc.seoul.kr

Purpose: Despite a large number of resting-state functional MRI (rsfMRI) studies in schizophrenia, current evidence on the abnormalities of functional connectivity (FC) of resting-state networks shows high variability, and the findings on recent-onset schizophrenia are insufficient compared to those on chronic schizophrenia.
Patients and Methods: We performed a rsfMRI in 46 patients with recent-onset schizophrenia and 22 healthy controls. Group independent component brainmap and dual regression were performed for voxel-wise comparisons between the groups. Correlation of the symptom severity, cognitive function, duration of illness, and a total antipsychotics dose with FC was evaluated with Spearman’s rho correlation.
Results: The patient group had areas with a significantly decreased FC compared to that of the control group in which it existed in the left supplementary motor cortex and supramarginal gyrus (the executive control network) and the right postcentral gyrus (the auditory network). The patient group had a significant correlation of the total antipsychotics dose with the FC of the cluster in the left supplementary motor cortex in the executive control network.
Conclusion: Patients with recent-onset schizophrenia have decreased FC of the executive control and auditory networks compared to healthy controls.

Keywords: schizophrenia, resting-state fMRI, executive control network, auditory network

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