Back to Journals » International Journal of General Medicine » Volume 12

A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud’s Of The Tongue

Authors Aqtash O, Ajmeri AN, Thornhill BA, Anderson E, Carroll R, Elhamdani A, Tackett E

Received 18 May 2019

Accepted for publication 17 September 2019

Published 23 October 2019 Volume 2019:12 Pages 381—385


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Obadah Aqtash,1 Aman Naim Ajmeri,1 Brent A Thornhill,1 Elise Anderson,2 Ryan Carroll,1 Adee Elhamdani,1 Eva Tackett1

1Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA; 2Charleston Area Medical Center, Charelston, WV 25701, USA

Correspondence: Aman Naim Ajmeri
Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA, 

Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially fatal severe adverse reaction to medications. Numerous drugs have been implicated, with carbamazepine and allopurinol being the most common. Tenofovir-induced DRESS is extremely rare. We report a case of a 65-year-old male patient with a diffuse exfoliative maculopapular rash across his entire body of five weeks of duration. The patient also had icteric sclera, abnormal liver enzymes and Raynaud’s of the tongue, nose and the left fifth finger. After discontinuation of tenofovir, the case resolved over a span of ten days. A high index of suspicion is crucial along with the prompt withdrawal of the offending medication for a good outcome.

Keywords: DRESS, drug reaction with eosinophilia and systemic symptoms, tenofovir, tenofovir-induced DRESS, Raynaud’s phenomena, Raynaud’s of the tongue

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]