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A survey of adult referrals to specialist attention-deficit/hyperactivity disorder clinics in Canada

Authors Klassen LJ, Blackwood CM, Reaume CJ, Schaffer S, Burns JG

Received 30 June 2017

Accepted for publication 17 October 2017

Published 22 December 2017 Volume 2018:11 Pages 1—10

DOI https://doi.org/10.2147/IJGM.S145269

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Larry J Klassen,1 C Matthew Blackwood,2 Christopher J Reaume,3 Samuel Schaffer,3 James G Burns3

1Eden Mental Health Centre, Winkler, MB, 2Cedar Care Clinic, Mission, BC, 3International Medical Affairs, Shire Pharma Canada ULC, Toronto, ON, Canada

Background: Canadian guidelines encourage family physicians to diagnose/manage adults with uncomplicated attention-deficit/hyperactivity disorder (ADHD); specialist referral is recommended only for complex cases. This retrospective case review investigated adults referred to Canadian ADHD clinics.
Methods: Adult ADHD specialists reviewed referral letters/charts of patients (aged ≥18 years and no family history/known/expressed childhood ADHD) from family physicians/psychiatrists over 2 years.
Results: Data on 515 referrals (mean age 33 years, 60% males) were collected (December 2014 to September 2015); 472/515 (92%) were made by family physicians. No psychiatric comorbid symptoms were noted in 344/515 (67%) referrals. ADHD was confirmed by a specialist in 483/515 (94%) cases, whether comorbid symptoms were noted at referral (155/171 [91%]) or not (328/344 [95%]). ADHD was reported to impact “work” (251/317 [79%]), “school” (121/166 [73%]), “social/friends” (260/483 [54%]), and “spouse/family” (231/483 [48%]). Overall, 335/483 (69%) patients had more than or equal to one comorbid symptom (diagnosed by referring physician or specialist). Stimulant monotherapy was recommended for 383/483 (79%) patients, non-stimulant monotherapy for 41/483 (8%) patients, and stimulant plus non-stimulant monotherapy for 39/483 (8%) patients. Almost half of patients were returned for referring physician’s follow-up, either before treatment initiation (102/483 [21%]) or after treatment stabilization (99/483 [20%]). Follow-up was by a specialist for 282/483 (58%) patients.
Conclusion: ADHD diagnosis was specialist confirmed in most cases. Although most referrals (67%) noted no psychiatric comorbid symptoms, 69% of patients had ≥1 such symptom (diagnosed by a referring physician or specialist), so comorbid symptoms although not always noted at referral, may have contributed to the decision to refer. ADHD has a wide-ranging impact on patients’ daily lives. It is possible that greater confidence of family physicians to diagnose and treat adult ADHD could help to meet patients’ needs.

Keywords: attention-deficit/hyperactivity disorder, adult, Canada, diagnosis, comorbid symptoms, family medicine/general practice/primary care

Introduction

Attention-deficit/hyperactivity disorder (ADHD) is a disabling neurobehavioral disorder characterized by core symptoms of inattentiveness, hyperactivity, and impulsivity. Although traditionally perceived as a disease of childhood and adolescence, ADHD has a prevalence of up to 5% in adults1 in whom it causes functional impairment and adversely affects health-related quality of life.2 Adults with ADHD are more likely than their non-ADHD counterparts to experience difficulties with academic studies, employment, and emotional relationships and to commit a criminal offense or display antisocial behavior.3 Comorbid psychiatric disorders occurring with ADHD are commonplace in adults with ADHD,46 and comorbid impulsive disorders and substance use may further complicate patient management.7

Diagnosis/treatment of adult ADHD tends to be offered by only a limited number of specialist centers.8 The use of specialist care alone is not a viable health care model, and Canadian guidelines encourage family physicians to diagnose/manage adults with uncomplicated ADHD within primary care.9 Specialist referral is recommended only for complex cases, such as when there are comorbid conditions, if another diagnosis could be possible (i.e., disorders that mimic ADHD), or there is a need for management with multiple interventions or medications.9 In such cases, once the patient is assessed and treatment initiated, follow-up can be undertaken by the family physician.9 In reality, many family physicians are reluctant to diagnose and treat even uncomplicated adult ADHD, likely due to various reasons including the need to rely on subjective reports of symptoms, subtle differences in symptoms of ADHD in adults compared to those in children/adolescents, and a perceived need to adopt a cautious approach in prescribing stimulant treatment.10 Inadequate training in ADHD and comorbidities may also contribute to this reluctance. The objective of this survey was to evaluate whether family physicians diagnosed and treated uncomplicated ADHD (as per the recommendation) through investigation of the referral of adult patients by family physicians to ADHD specialist clinics, as well as to examine the impact of adult ADHD on daily life. This was explored by conducting a case review of the clinical presentation, disease burden, and treatment of adults referred to adult ADHD specialist clinics in Canada. Specifically, the survey assessed information regarding comorbid symptoms, impact of ADHD on life function, types of medication prescribed, and delay from referral to treatment.

Methods

Study design and setting

This was an open-label, noninterventional, retrospective survey of referrals of adults with suspected ADHD from family physicians or nonspecialist psychiatrists to a specialist in adult ADHD. Data were collected between December 2014 and September 2015 from original referral letters and ADHD specialists’ charts and used to complete a case report form (CRF) for each patient. Data were anonymized; patients were not identifiable and could not be linked back to a specific site. The survey was reviewed and approved by the Canadian SHIELD Ethics Review Board. As data were de-identified and complied with the patient confidentiality requirements of the ethics review board, patient consent was not obtained for this study.

Study population

Canadian adult ADHD medical specialists (physicians specializing in adult ADHD and practicing at clinics in Canada and who were recognized by their local communities as ADHD specialists) were identified and contacted via fax and/or email to request their participation; 19 specialists participated in the study.

Inclusion criteria

Referrals of adults (≥18 years of age at the time of ADHD diagnosis) to adult ADHD specialists made in the previous 2 years were included if ADHD was suspected by the family physician (as indicated in the referral note).

Exclusion criteria

Patients were excluded if they had an expressed or known prior family history of ADHD or an expressed or known childhood history of ADHD.

Survey instrument

A CRF was completed for each patient detailing the information listed in Table S1, including patient demographics (age, sex, employment status) and the measurements described below (see Measurements section).

Accuracy of the survey instrument

Data entry from each CRF was performed by an independent data entry specialist from Drug Intelligence Inc. (Toronto, Canada), and double data entry verification was used to ensure the accuracy of data entry.

Measurements

Reasons for referral to adult ADHD specialist

Reasons for referral included the referring physician mentions ADHD or symptoms implying ADHD, with no comorbid symptoms noted; the referring physician mentions ADHD with other comorbid symptoms; the patient/family suspects ADHD with no comorbid symptoms noted; the patient/family suspects ADHD and the patient has comorbid symptoms; or the patient mentions symptoms not limited to ADHD.

Delay from referral request to actual patient consultation by ADHD specialist

This delay was the time in months between referral and initial consultation with an ADHD specialist.

Prevalence of ADHD symptoms

Data were combined from the “reason/trigger for consultation request as per referral note”, “complaints verbalized by patient to ADHD specialist at initial assessment”, and “ADHD symptoms as interpreted by ADHD specialists” sections of the CRFs. Two observers (JGB and SS) independently reviewed the data to list the symptoms for each patient according to predefined categories (Table S2).

Prevalence of comorbid symptoms

Comorbidities were reported in CRFs but not always stated as a specific, confirmed Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnosis11 and thus were interpreted only as “comorbid symptoms”. Comorbid symptoms included (with examples of wording) depression (e.g., major depressive disorder, depression), anxiety (e.g., social anxiety disorder, generalized anxiety disorder, anxiety), other mood disorders (e.g., bipolar disorder, dysthymia), substance abuse (e.g., opioid addiction, alcohol abuse disorder, substance abuse), and other (e.g., Tourette’s, obsessive–compulsive disorder, borderline personality disorder).

Impact of ADHD on patients’ daily life

The impact of ADHD on school/work, relationships with spouse/family, social life and friends, money management, and other areas was reported by the specialist and categorized.

Employment status

Four patient profiles with respect to status of employment were described post hoc: college/university student, employed young adult (18–25 years old), employed adult (>25 years old), and unemployed adult (>25 years old).

Follow-up care after ADHD diagnosis

The use of pharmacologic ADHD treatments prescribed by the specialist (stimulant monotherapy, non-stimulant monotherapy, stimulant plus non-stimulant) after diagnosis (also by the specialist) was recorded. Continuing care was described as follows: patients returned to the care of the referring physician, patients stabilized on treatment and then returned to the care of their referring physician, or follow-up retained by the specialist. The data comparing those patients who were retained by the ADHD specialist versus those who were sent back to the referring physician (with or without initiation of treatment) were explored further to investigate whether any patient characteristics such as sex, age, or comorbid symptoms affected the course of continuing care.

Statistics

Data from this survey were descriptive. No inferential statistical analyses were performed.

Results

Participants

A total of 515 referrals fitting the inclusion criteria were collected (one referral did not meet inclusion criteria). Of the 19 specialists, 10 were interviewed over phone by Drug Intelligence Inc. to complete the CRFs; nine specialists completed the CRFs directly. The demographic characteristics of the referrals, both for the overall sample and by ADHD status, are summarized in Table 1. Of the 515 cases, 483 (93.8%) had an ADHD diagnosis made by the adult ADHD specialist. The mean age at referral was 33 years; 60.2% of referrals were males. There was no difference in mean age between males and females.

Table 1 Patients’ demographic characteristics for the overall sample and by ADHD status

Note: Percentage may not add to 100% due to rounding.

Abbreviation: ADHD, attention-deficit/hyperactivity disorder.

Analyses

Reasons for referral to adult ADHD specialist

Triggers for patient referral were referring physician mentions ADHD or symptoms implying ADHD, with no comorbid symptoms noted (59.2%; 305/515); referring physician mentions ADHD with other comorbid symptoms (15.3%; 79/515); patient/family suspects ADHD (7.6%; 39/515) with no comorbid symptoms noted; patient/family suspects ADHD and patient has comorbid symptoms (2.5%; 13/515); or patient mentions symptoms not limited to ADHD (15.3%; 79/515). Most (91.7% [472/515]) referrals were made by family physicians, 5.8% (30/515) were made by nonspecialist psychiatrists, and 2.5% (13/515) were referred by “other” physicians, e.g., a psychologist.

Delay from referral request to actual patient consultation by ADHD specialist

One-third of patients had a delay of ≥3 months between referral and initial consultation with an adult ADHD specialist; 31% were seen by a specialist within a month (Figure 1).

Figure 1 Delay between referral and the initial consultation with the adult ADHD specialist (n=505a).

Note: aA total of 10 of the 515 patients’ CRFs did not have the referral date and are not included in this figure.

Abbreviations: ADHD, attention-deficit/hyperactivity disorder; CRF, case report form.

Prevalence of ADHD symptoms

Inattention was the predominant symptom for patients with confirmed ADHD and was experienced by ~80% of patients (Figure 2). Other commonly reported ADHD symptoms were procrastination, disorganization, impulsivity, hyperactivity, emotional dysregulation, and memory impairment.

Figure 2 Prevalence of ADHD symptomsa among patients with confirmed ADHD (n=483).

Notes: aCombined from reason for referral, complaints as verbalized by the patient, and symptoms as interpreted by the specialist. Patients could have more than one symptom.

Abbreviation: ADHD, attention-deficit/hyperactivity disorder.

Prevalence of comorbid symptoms

No psychiatric comorbid symptoms were noted by the referring physician in 66.8% (344/515) of case referrals. In total, 69.4% (335/483) of patients with confirmed ADHD had ≥1 comorbid symptom (reported by either the specialist or the referring physician). Anxiety and depression were the most common psychiatric comorbid symptoms (Figure 3).

Figure 3 Prevalence of comorbid symptomsa noted by the specialist or the referring physician among patients with confirmed ADHD (n=483).

Notes: aComorbidities were interpreted only as “comorbid symptoms” as they were not always reported in the CRFs as a specific, confirmed DSM-5 diagnosis. Patients could have more than one comorbid symptom.

Abbreviations: ADHD, attention-deficit/hyperactivity disorder; CRF, case report form; DSM-5, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition.

Impact of ADHD on patients’ daily life

Almost all (99.6% [481/483]) patients with confirmed ADHD reported an impact on their daily life. School or work were particularly affected (Figure 4).

Figure 4 Impact of ADHD on daily life of adults with confirmed ADHD (n=483).

Notes: Patients could report impact on more than one area of daily life. aIncludes all college/university students with confirmed ADHD (n=166). bIncludes all patients except college/university students with confirmed ADHD (n=317).

Abbreviation: ADHD, attention-deficit/hyperactivity disorder.

Employment status

All but 17.2% (83/483) of patients with confirmed ADHD were either employed (48.4%; 234/483) or a college or university student (34.4%; 166/483).

Follow-up care after ADHD diagnosis

In patients diagnosed with ADHD, pharmacological ADHD treatments were recommended as follows: stimulant monotherapy, 79.3% (383/483); non-stimulant monotherapy, 8.5% (41/483); and stimulant plus non-stimulant, 8.1% (39/483); a stimulant/non-stimulant medication was not recommended for 4.1% (20/483) of patients. Patients were returned to the care of the referring physician in 21.1% (102/483) of cases. A further 20.5% (99/483) of patients were stabilized on treatment and then returned to the care of their referring physician. Follow-up was retained by the specialist in 58.4% (282/483) of patients with ADHD. Although no statistical testing was performed, patient characteristics (sex, age, or comorbid symptoms) did not appear to influence which patients were retained by the specialist and which patients were sent back to the referring physician; conversely, there was considerable variability between adult ADHD specialists in the percentage of patients who were retained. For example, one physician retained no patients, another retained 10%, and three physicians retained 100% of patients.

Discussion

The results from this survey of referral patterns provide valuable insights into diagnosis and treatment of uncomplicated ADHD in adults in real-world practice in Canada. Following referral of patients with suspected symptoms of ADHD by family physicians, the diagnosis of ADHD was confirmed by a specialist in most cases, thereby indicating that the family physicians were able to correctly identify ADHD patients in their practice. This agreement between primary and specialist care was achieved despite infrequent use of standardized instruments for ADHD diagnosis in daily practice. In the majority of cases (66.8%), no psychiatric comorbid symptoms were noted by the referring physician at the time of referral. Therefore, although cases appeared unlikely to be complex from the case notes, the patients were still referred to specialists. However, as many patients (69.4%) had at least one comorbid symptom noted (reported by either the specialist or the referring physician), it cannot be excluded that a comorbid symptom (although not always noted by the referring physician) contributed to the decision to refer.

The demographic data collected in this survey are consistent with published epidemiological data, which suggest that adult ADHD is more likely to be diagnosed in males than females.5 ADHD is often associated with high levels of unemployment compared with the general population1214 and with “on-the-job difficulties” in students.15 Indeed, data from an international web-based survey of adults in Europe and the US showed that, compared to individuals without ADHD, those with ADHD were less likely to be employed (55.3% versus 64.2%, respectively, in Europe and 62.0% versus 78.0%, respectively, in the US).16

In this survey, 17% of the ADHD population was unemployed, compared with an unemployment rate of 7% overall in Canada.17 The high rates of unemployment could also be attributed to psychiatric comorbid symptoms, as the unemployment rate for individuals with mood and anxiety disorders is higher than that in the general population.18 The survey highlighted delays from referral request to consultation with an ADHD specialist; for adults without comorbid symptoms (approximately one-third of adults in this study), these delays could be avoided if family physicians were trained and more confident in dealing with uncomplicated cases of adult ADHD. Referrals to specialist clinics in Canada for adult ADHD were predominantly for patients with common ADHD symptoms such as inattention (reported in 80% of cases). This finding is consistent with a published survey of 3574 patients with adult ADHD in which inattention was the most common and disabling symptom.19 Where psychiatric comorbid symptoms were noted, the most common were anxiety and depression, which is consistent with reports in the literature.5

Data from this survey showed that ADHD had a multifaceted impact on patients’ daily lives, affecting work and school, as well as relationships and finances. This pattern of negative impact on aspects of workplace/social functioning is consistent with data reported in the literature.2 Indeed, significant impairment of day-to-day functioning, cognition, and social interactions are reported in the literature for adults with ADHD, irrespective of comorbidities.5 Specialist consultation was delayed by ≥3 months in one-third of referrals. If these cases could have been managed within primary care, this delay in receiving a diagnosis and treatment would not have occurred. Approximately 40% of patients were returned to the referring physician either immediately or after stabilization on treatment, suggesting that a considerable number of cases could potentially have been managed within primary care. No specific trends were shown for which patients were retained by the ADHD specialist versus which patients were returned to the referring physician.

In patients diagnosed with ADHD, pharmacologic ADHD treatments were recommended in >95% of cases, with stimulant monotherapy the most frequently prescribed (79.3%). Family physicians in Canada may not only be reluctant to diagnose adult ADHD but also may lack confidence in prescribing treatments for ADHD.20 This may be due to a lack of experience in managing ADHD throughout the patient’s lifespan and the confusion created by comorbid symptoms. It remains to be seen if reluctance by physicians to prescribe pharmacologic treatments for ADHD may also be affected by the inclusion of psychostimulants in the safe prescribing standard of care document published by the College of Physicians and Surgeons of British Columbia (CPSBC) in June 2016.21

Canadian guidelines state that “in Canada, adequate levels of service delivery for ADHD are only going to be feasible when it becomes a disorder that primary care providers are trained to deal with, and when they can access specialist care when needed”. The Canadian guidelines recommend that family physicians diagnose and treat uncomplicated ADHD in adults and acknowledge that where cases are more complicated, referral to a specialist is advisable. However, following diagnosis and treatment by the specialist, continuing care may be provided by family physicians, even in more complicated cases.9 In order to cope with the challenge of managing adult ADHD and the burden that it places on the health care system, primary care physicians may need additional education and support.9

Limitations

The interpretation of the results reported here should be viewed with caution because of the descriptive and retrospective nature of the data. Information on psychiatric comorbid symptoms at the time of referral was reliant on information provided by the family physician at referral; therefore, assessment of comorbid symptoms was performed in a nonstandardized manner in this study. In addition, there was insufficient information (both from the family physician and the specialist) to report comorbidities as diagnosed conditions, and so we have used the term comorbid symptoms. Additional limitations include the lack of data for lifetime versus current comorbid symptoms. Adults were only included in the survey if they had no obvious family history of ADHD; however, it should be noted that information about family history of ADHD by its nature may be unreliable. The study was designed to provide information on the typical patients and patient flow that are seen in the process of referral to adult ADHD specialists in Canada. However, the authors acknowledge that inclusion of a larger number of cases would enhance the information gained from the survey.

Conclusion

The results from this survey of adult referrals in Canada showed that ADHD diagnosis was specialist confirmed in most cases, showing that the referring practitioner was correct in his or her suspected diagnosis of ADHD. Although appropriate referral is important and family physicians should feel comfortable with referring their patients to specialists when necessary, referrals were made even when patients presented with predominantly common ADHD symptoms and no apparent psychiatric comorbid symptoms. This could indicate that family physicians are less confident in diagnosing adult ADHD. However, although in most referrals (67%), no psychiatric comorbid symptoms were noted, 69% of patients had ≥1 such symptom (reported by the specialist or referring physician), so it may be that comorbid symptoms, although not always noted at referral, contributed to the decision to refer.

Measures such as relevant training including better knowledge of current pharmacologic treatments and correct use of available guidelines are needed to reinforce family physicians’ confidence in diagnosing uncomplicated cases of suspected adult ADHD. This could also be extended to educational initiatives to increase family physicians’ confidence in diagnosing comorbid ADHD. The fact that around two-thirds of adults with ADHD have comorbid symptoms brings into question the practicality of the Canadian guidelines in advising that only uncomplicated ADHD is treated by family physicians.

Family physicians may feel able to manage the follow-up of a case once diagnosis has been confirmed by the specialist. This should boost confidence in their ability to diagnose ADHD with comorbid symptoms, eventually resulting in fewer referrals to specialty clinics. This trend could be examined in a future study, with the hope that results may show a reversal of the current disconnect between primary and specialist care. Improvements in training and education of family physicians may result in faster access to treatment, ultimately reducing the impact of untreated ADHD on various aspects of patients’ daily lives.

Acknowledgments

The authors wish to thank the ADHD specialists who contributed case information for this survey. Under the direction of the authors, Joanna Wright, DPhil, Caudex, Oxford, UK, and Denise Graham, PhD, Caudex, Oxford, UK, provided writing assistance for this publication, funded by Shire International GmbH. Editorial assistance in formatting, proofreading, copyediting, fact checking, and coordination and collation of comments was also provided by Caudex, funded by Shire International GmbH. The authors wish to thank Carol Heggie (formerly of Shire) for her contribution to the study. Tamara Werner-Kiechle of Shire International GmbH also reviewed and edited the manuscript for scientific accuracy. Although employees of Shire were involved in the design, collection, analysis, interpretation, and fact checking of information, the content of this manuscript, the interpretation of the data, and the decision to submit the manuscript for publication in International Journal of General Medicine were made by the authors independently. This research was funded by Shire Development, LLC. Shire International GmbH provided funding to Caudex, Oxford, UK, for support in writing and editing this manuscript. Data from this manuscript were presented at the 12th Annual CADDRA ADHD Conference, Ottawa, Canada, 2016.

Author contributions

James G Burns and Samuel Schaffer contributed to the conception and design of the study. All authors contributed to the analysis and interpretation of the data and revised the article critically for content. All authors reviewed and approved the final draft of the manuscript and have agreed to act as guarantors of the work.

Disclosure

Larry J Klassen has received research support from Shire and has been on advisory boards and speaker bureaus for Shire, Ironshore, Janssen, Lundbeck, Pfizer, Purdue, and Sunovion. C Matthew Blackwood has been on advisory boards and speaker bureaus for Shire and is on the Board of Directors for CADDRA. Christopher J Reaume and James G Burns are employees of Shire. Samuel Schaffer was an employee of Shire at the time of the study. The authors report no other conflicts of interest in this work.

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Supplementary materials

Table S1 CRF

Abbreviations: ADHD, attention-deficit/hyperactivity disorder; CRF, case report form; FM, family medicine; GP, general practitioner; MD, Doctor of Medicine.

Table S2 Categories and predefined list of words used to list the symptoms for each patient

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