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A Simple Scoring Algorithm That Predicts Abscesses in Adults with Community-Onset Klebsiella pneumoniae Bacteremia: Hypermucoviscosity Matters

Authors Hong MY, Hsieh CC, Yang CY, Lee CH, Ko WC, Lee CC

Received 2 December 2019

Accepted for publication 25 March 2020

Published 14 April 2020 Volume 2020:13 Pages 1045—1055

DOI https://doi.org/10.2147/IDR.S240809

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Professor Suresh Antony


Ming-Yuan Hong,1,2 Chih-Chia Hsieh,1,2 Chao-Yung Yang,1 Chung-Hsun Lee,1,2 Wen-Chien Ko,2,3 Ching-Chi Lee1,3– 5

1Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Department of Medicine, National Cheng Kung University Medical College, Tainan, Taiwan; 3Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 4Department of Adult Critical Care Medicine, Tainan Sin-Lau Hospital, Tainan, Taiwan; 5Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan, Taiwan

Correspondence: Wen-Chien Ko
Division of Infectious Disease, Department of Internal Medicine, National Cheng Kung University Hospital, No. 138, Sheng Li Road, Tainan 70403, Taiwan
Tel +886-6-2353535 ext. 3596
Fax +886-6-2752038
Email winston3415@gmail.com
Ching-Chi Lee
Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, No.1, Changda Rd., Gueiren District., Tainan City 71101, Taiwan
Tel +886-6-2785123 Ext 3326
Fax +886-6-2990586
Email chichingbm85@gmail.com

Introduction: Klebsiella pneumoniae is a pathogen commonly found in community-onset bacteremia. It causes an invasive syndrome that is frequently presented by metastatic infections and abscesses elsewhere and that is necessary for surgical or drainage intervention. To achieve a scoring algorithm to identify patients with community-onset K. pneumoniae bacteremia (CoKPB) who are at risk for abscess occurrences, a retrospective cohort study consisting of adults with CoKPB was conducted.
Methods: A 6-year cohort study consisting of adults having community-onset monomicrobial K. pneumoniae bacteremia was conducted. In addition to clinical variables collected from medical records, the hypermucoviscosity (HMV)-related gene (rmpA and magA) and an HMV phenotype were integrated into the proposed scoring algorithm.
Results: Of the 258 eligible adults, only 79 (30.6%) had abscesses related to bacteremia. Besides the presence of magA (ie, capsular serotype K1) and the HMV-phenotype, five clinical predictors were significantly associated with abscesses in a multivariate analysis: male gender, comorbidities with diabetes mellitus or neurological disorders, recent chemotherapy, and high c-reactive protein levels. Together, these predictors were used to calculate the CoKPB abscess score. Based on the scoring algorithm, a cut-off value of +2 yielded the high sensitivity (93.7%) and the acceptable specificity (50.8%); the area under the ROC curve was 0.83.
Conclusion: A simple scoring algorithm that has substantial sensitivity and satisfactory specificity was proposed and the importance of the HMV phenotype or capsular K1 serotype was emphasized. The proposed predictive model needs external validation, but this scoring algorithm might be convenient and useful for clinicians.

Keywords: Klebsiella pneumoniae, bacteremia, hepatic abscesses, extrahepatic abscesses

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