Back to Journals » International Journal of General Medicine » Volume 14

A Review on Research Progress in the Application of Glycosylated Hemoglobin and Glycated Albumin in the Screening and Monitoring of Gestational Diabetes

Authors Liu X, Wu N, Al-Mureish A

Received 10 January 2021

Accepted for publication 8 March 2021

Published 30 March 2021 Volume 2021:14 Pages 1155—1165


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Xinyan Liu,1 Na Wu,1,2 Abdulrahman Al-Mureish1

1Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China; 2Clinical Skills Practice Teaching Center, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China

Correspondence: Na Wu Email [email protected]

Abstract: Glycosylated hemoglobin (HbA1C) and glycated albumin (GA) can be used for blood glucose management of a person with diabetes as a result of their convenience and stability. However, there is no corresponding standard for the application of glycosylated hemoglobin and glycosylated albumin in gestational diabetes mellitus (GDM). In this review, we summarize the published research and discuss three aspects of the significance of HBA1C and GA in GDM patients: screening of gestational diabetes mellitus, blood glucose monitoring and the relationship with pregnancy outcome. At present, studies suggest that HBA1C can be used as a screening indicator for pregnant women, but it cannot completely replace OGTT. HbA1C and GA can be used for blood glucose management in patients with GDM to reduce the incidence of GDM complications. However, the application of HBA1C and GA in GDM still needs more research and clinical practice support.

Keywords: blood glucose, diabetes mellitus, fasting blood glucose


Gestational diabetes mellitus (GDM) is defined as hyperglycemia with onset or recognition at first pregnancy, which is not overt diabetes.3 GDM is a common disease during pregnancy, and its incidence is increasing in line with improvements in standards of living and testing levels. According to an International Diabetes Federation survey conducted in 2017, the global prevalence of GDM has reached 16.2%.4 GDM can lead to a variety of adverse pregnancy outcomes that early diagnosis and proper control of blood glucose levels during pregnancy can reduce.5,6 Glycosylated hemoglobin is a non-enzymatic glycation product formed by the combination of hemoglobin and blood glucose. Its production is slow, continuous and irreversible and affects blood glucose levels within 2–3 months. Meanwhile, glycated albumin is the product of a non-enzymatic reaction between serum protein and glucose that is not affected by external factors such as red blood cell life but can affect blood glucose control within 2–3 weeks or even shorter periods.1,2 Glycosylated hemoglobin and glycated albumin can be used for blood glucose management of diabetic patients as a result of their convenience and stability. This review will discuss the significance, advantages and limitations of HbA1C and GA in patients with GDM.

Application of Glycosylated Hemoglobin and Glycated Albumin in Screening of Gestational Diabetes

According to ADA and FIGO standards, screening and diagnosis of GDM are currently based on an oral glucose tolerance test (OGTT) at 24–28 weeks' gestation.7,8 Some scholars are studying the application of HbA1C and GA in the screening of GDM. Some studies have shown that early screening of pregnant women can lead to early screening of GDM patients.9 The treatment of early GDM can improve impaired glucose tolerance in the second trimester, and reduce the incidence of GDM complications.6 At present, relevant studies believe that HbA1c in early pregnancy has a positive impact on the screening and diagnosis of GDM patients.10–19 For example, some studies suggest that patients with elevated HbA1c in the first trimester of pregnancy have an increased risk of GDM.10 Some studies have also shown that an increase of HbA1c can predict GDM.11–14 Fong et al suggest that patients with early HbA1c elevation need to be more closely monitored and possibly screened for GDM.12 Some studies have also found that early measurement of HbA1c can be used to diagnose GDM.15–19 At present, however, research institutes choose different periods for measuring HbA1c in early pregnancy (from 8 weeks to 20 weeks), and research cut-off points also vary, which limitsa application of their findings.

For patients in the second trimester, some research considered that HbA1C was statistically significantly different between persons with GDM and normal pregnant women, and the ROC curve suggested good sensitivity as well as specificity. But the cut-off point for HbA1C in diagnosing GDM is not uniform at present, ranging from 5.45–6, and limits its application in screening.20–23 Renz et al considered the different cut-off points of HbA1C for the diagnosis of GDM to be 5.7, 5.8 or 6.0; however, regardless of the cut-off value used, negative results require further sensitive tests to confirm the diagnosis.24 It has also been suggested that HbA1C can be used as a screen for GDM, which would enable some pregnant women to avoid unnecessary OGTT.24,25 Ye et al concluded that OGTT should be performed for women with HbA1C values between 4.8 and 5.5.24 Rajput et al suggested that an OGTT should be performed for women with HbA1C values between 5.45 and 5.95, and women with an HbA1C value of 61.8 could avoid OGTT.25 However, some scholars found that HbA1C is not meaningful for the screening of GDM.26–30

The current study found that the application of GA for the screening of gestational diabetes is still controversial.31–33 Recent studies have shown that HbA1C as well as GA combined with indicators such as FBG and BMI can be predictive of GDM.34–40

For GDM patients, OGTT at 24–28 weeks' gestation is still an important basis for the diagnosis of GDM. Combined with the current research, HbA1c and GA cannot replace OGTT. This may be because OGTT can accurately reflect the blood glucose level of patients, and there is a unified standard. HbA1c and GA have their limitations in application. For example, HbA1c may be affected by anemia and kidney disease.41 Anemia is very common in pregnant women, especially in late pregnancy. Some studies suggest that weight and other factors may affect GA value during pregnancy, leading to the limitation of GA application.32 Moreover, different races and different monitoring methods may lead to different levels of HbA1c.42 However, it is not convenient for pregnant women to have to take a certain amount of glucose on an empty stomach and measure their blood glucose three times within two hours. However, HbA1c and GA are not limited by time and only need to be measured once, which is a relatively convenient process. The current research reveals that HbA1c and GA can also be significant in the diagnosis of GDM (see Table 1). Phase studies suggest that HbA1c in early pregnancy can help early screening and diagnosis of GDM. At present, the diagnosis results of HbA1c and GA in the second trimester are not consistent. Some researchers think that HbA1c can aid diagnosis; others think that HbA1c cannot be diagnosed but can help to screen out patients who need further OGTT. HbA1c and GA combined with other indicators also provide new ideas for the diagnosis of patients experiencing difficulty in improving OGTT.

Table 1 Application of HbA1C and GA in Screening of Gestational Diabetes

Application of Glycosylated Hemoglobin and Glycated Albumin in Blood Glucose Monitoring of Patients with Gestational Diabetes

GDM can lead to various pregnancy complications including eclampsia, pregnancy-induced hypertension, miscarriage, premature birth, macrosomia, neonatal hypoglycemia, neonatal jaundice, neonatal respiratory distress, etc. In the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, increased blood glucose levels were associated with adverse pregnancy outcomes.5 Some studies consider the elevation of HbA1C to be associated with neonatal complications17,30,43–55 (see Table 2). The American Diabetes Association (ADA) considers that the incidence of adverse fetal outcomes is lowest when HbA1C<6 in early pregnancy.45 Elizabeth et al consider that HbA1C≥ 6.5 in the third trimester increases the probability of neonatal hypoglycemia.46 Some studies suggest that a higher HbA1c is associated with an increased probability of neonatal macrosomia.30,47 Sweeting et al consider that HbA1C≥5.9 at first trimester is associated with an increased probability of macrosomia.47 Ho et al consider that an increased probability of macrosomia is associated with HbA1C≥ 5 in the second trimester.30 The ADA study, however, suggests that HbA1C may not accurately reflect postprandial hyperglycemia, which is associated with greater macrosomia, and thus is not related to macrosomia.45

Table 2 Relationship Between HbA1C, GA and Infant Complications

Some studies find that higher HbA1C is associated with an increased probability of LGA (large for gestational-age infants).30,43,45,47,48,50 The ADA considers that HbA1C< 6 at mid and late pregnancy is associated with a minimization of LGA risk.45 Sweeting et al suggest that HbA1C>5.9 at first trimester is associated with an increased probability of LGA.47 Morris et al suggest that HbA1C>6 at first trimester is associate with increased probability of LGA.48 Ho et al consider that an increased probability of LGA is associated with HbA1C≥5 in the second trimester.30 Antoniou et al suggest that HbA1C>5.5 in third pregnancy is associated with an increased probability of LGA.49 Barquiel et al suggest that HbA1C>5.5 at late pregnancy is associated with an increased probability of LGA.43 Morris et al find that HbA1C≥6 at first trimester is associated with an increased probability of hyperbilirubinemia.48

Some studies suggest that high HbA1C increases the probability of congenital malformations. Inkster et al found it possible to calculate a relative risk reduction of congenital malformation for each 1-percent decrease in HbA1C, which varied from 0.39 to 0.59.51 Hughes et al find that an increased probability of congenital malformation is associated with HbA1C>5.9 at first trimester.18 Ho et al suggest that HbA1C>5 at second trimester is associated with a higher probability of NICU admission and perinatal mortality.30 In addition to increased HbA1C being associated with increased probability of infant complications, Bi et al suggest that a normal HbA1C range is an independent risk factor for preterm delivery, macrosomia and LGA and that a lower HbA1C helps prevent adverse birth outcomes.52 Some other researchers argue that GA is more relevant in terms of infant complications. Li et al53 consider that the risk of macrosomia is significantly increased if GA≥13.00 at 24–28 weeks' gestation and GA ≥12.00 at 36–38 weeks' gestation. Sugawara et al54 consider that when HbA1C is not statistically different, the risk of infant complications increases if GA≥15.80. Mendes et al55 consider that GA is correlated with the neonatal complications of GDM patients while there is no significant correlation between HbA1C and the neonatal complications of GDM patients.

Some scholars suggest that the elevation of HbA1C is associated with other maternal complications18,30,45,47,56–58 (see Table 3). The ADA suggests that HbA1C<6 at mid-pregnancy is associated with the lowest risk of maternal complications.45 Some research suggests that premature abortion and the probability of cesarean section are associated with higher HbA1C.30,47,57 Some studies consider that the elevation of HbA1C is related to gestational hypertension and preeclampsia.17,30,47,56 Other studies suggest that elevated first- trimester HbA1C is associated with severe maternal morbidity (SMM) or risk of death.17,58 Hughes et al18 suggest that HbA1C≥5.9 at first trimester is associated with an increased risk of SMM or death, and Ray et al suggest that HbA1C≥6.5 at first trimester is associated with an increased risk of SMM or death.58

Table 3 Relationship Between HbA1c, GA and and Maternal Complications

The above studies consider that poor control of HbA1C and GA are associated with pregnancy outcomes. They suggest that we can reduce the occurrence of complications by controlling HbA1C as well as GA. But there are still some problems that need to be solved. First, the cut-offs and conclusions are different for different ethnicities and experimental methods. For example, Mañé et al59 suggest that HbA1C is not associated with pregnancy outcomes in Caucasians and the cut-offs varied among other ethnicities. Second, current studies also consider that blood glucose in different gestational periods is associated with different complications. For example, some studies found that macrosomia and LGA are associated with blood glucose in the second and third trimesters, and other studies found that neonatal malformations are associated with an increased risk of maternal glycemia in the first trimester.60,61 Thus the different targets of HbA1C at different periods with different ethnicities and experimental methods need to be confirmed. Current studies suggest that GA is more associated with infant complications related to gestational diabetes. However the research is not large enough and there is a need for further studies.

Besides maternal and fetal complications during pregnancy, GDM patients are associated with an increased risk of developing postpartum glucose intolerance compared with normal pregnant women.62,63 GDM patients should thus be screened postpartum. GDM patients are associated with postpartum glycemia, insulin resistance and beta-cell dysfunction.64 Some studies suggest that HbA1C is associated with abnormal postprandial glucose tolerance,65–68 and can be used for postpartum blood glucose monitoring. Katreddy et al67 conclude that HbA1C can be used for screening of diabetes in GDM in the early postpartum period. Kim et al68 consider that HbA1C has a lower association with single measures of glucose in the postpartum year but HbA1C>5.7 can still help screen for abnormal postpartum glucose tolerance. Some studies believe that the combination of HbA1c and FBG may be useful to identify women with glucose intolerance.69–71

Application of Glycosylated Hemoglobin and Glycated Albumin in Blood Glucose Monitoring of Patients with Gestational Diabetes

As mentioned above, adverse maternal and infant outcomes in patients with GDM are significantly associated with maternal blood glucose. Therefore, the blood glucose management of patients with GDM is very important. Relevant studies consider HbA1C and GA during pregnancy to be associated with glycemia in pregnant women.72,73 What should be noted is that the values ofHbA1C and GA differ in pregnancy and non-pregnancy. Nielsen et al consider that the normal range for HbA1C decreases from 6.3 to 5.7 in the first trimester to 5.6 in the third trimester.74 Hiramatsu et al illustrate that GA declines gradually during pregnancy, and the reference range for GA is 11.5–15.7.75 The ADA suggests that HbA1C can be used for glucose monitoring of patients with gestational diabetes, ideally with a target of HbA1C 6–7 in the first trimester and HbA1C< 6 in the second to third trimesters.45 Hashimoto et al suggest that HbA1C results may be affected by iron deficiency anemia in some pregnant women.42 However, GA is not affected by external factors such as red blood cell lifespan and can respond to shorter periods of addressing blood glucose levels. GA can also better respond to situations of postprandial hyperglycemia and fluctuations in blood glucose.76 Thus, it could reflect the glycemic status of GDM patients more precisely. Dong et al demonstrate that GA not only monitors blood glucose control but also emphasizes the severity of the condition because the value of GA may increase as the condition worsens.77 The basic treatment for GDM is lifestyle management and insulin therapy.78 Some studies suggest that glycemic management of GDM patients should be enhanced when HbA1C and GA are poorly controlled.79,80 Others consider that HbA1c is a reference for insulin therapy but the cut-offs are different.81–86 Tang et al consider that patients with HbA1C≥5.3 require treatment with insulin.81 González-Quintero et al consider that patients with HbA1C≥6 require treatment with insulin.82 Ducarme et al consider that patients with HbA1C≥5.4 and Bakiner et al consider that patients with HbA1C>5.485 should be treated with insulin.83,84 Vintzileos and Thompson suggest that glycated hemoglobin can be used as an indicator of long-term glycemic control and helps to evaluate the efficacy of treatment.86 Pan et al suggest that, compared with HbA1C, GA is more closely related to fasting and postprandial blood glucose levels, can accurately reflect the change of blood glucose, and might be a better monitoring indicator for GDM patients treated with insulin or diet.87

Some studies found that pregnant women with a negative OGTT may have impaired glucose tolerance in the third trimester due to weight gain.88 Ensenauer et al believe that HbA1C≥5.7 at delivery can help screen obese women with negative OGTT for advanced glucose intolerance, which can indicate further health management for the mother as well as the infant to reduce negative pregnancy outcomes.89


Glycosylated hemoglobin and glycated albumin can be used for the blood glucose management of diabetic patients. We discussed published reports from different periods and countries. Most researchers found that HbA1c and GA can be used for screening and management of GDM. The International Association of Diabetes and Pregnancy Study Groups (IADPSG) suggests that HbA1c can be used to screen for gestational diabetes; however, a single test alone is not feasible and cannot yet replace an OGTT for diagnosis.90 Current studies consider that HbA1c is a feasible indicator for screening pregnant women and selecting those who need further OGTT, while HbA1c in combination with other indicators such as GA can be applied for diagnosis. Current studies consider that both HbA1c and GA are associated with blood glucose during pregnancy and poor control of HbA1c as well as GA during pregnancy is associated with adverse pregnancy outcomes. Thus, HbA1c and GA can be applied to manage GDM and reduce complications of GDM. However, there are still some questions which require more research and clinical practice to answer. First, the standard of HbA1c and GA in different gestational periods, different ethnic groups and different detection methods needs further research. The values of HbA1c and GA for diagnosing GDM still require further research. Second, the relationship of different pregnancy outcomes with different gestational periods as well as cut-off points needs to be refined again. Finally, the target of glycemic control needs to be further researched.


HbA1c and GA may be good indicators for screening and management of GDM. However, the application of HBAIC and GA in GDM still needs more research and clinical practice support.


This research was supported by the National Natural Science Foundation of China (No.81700706), the 345 Talent Project of Shengjing Hospital, the Clinical Research Project of Liaoning Diabetes Medical Nutrition Prevention Society (No.LNSTNBYXYYFZXH-RS01B) and the Science Foundation of Liaoning Education Department (No. LK201603).


The authors report no conflicts of interest in this work.


1. Jovanovic L, Savas H, Mehta M, Trujillo A, Pettitt DJ. Frequent monitoring of A1C during pregnancy as a treatment tool to guide therapy. Diabetes Care. 2011;34(1):53–54. doi:10.2337/dc10-1455

2. Desouza CV, Holcomb RG, Rosenstock J, et al. Results of a study comparing glycated albumin to other glycemic indices. J Clin Endocrinol Metab. 2020;105(3):677–687. doi:10.1210/clinem/dgz087

3. Goyal A, Gupta Y, Singla R, Kalra S, Tandon N. American Diabetes Association “standards of medical care-2020 for gestational diabetes mellitus”: a critical appraisal. Diabetes Ther. 2020;11(8):1639–1644. doi:10.1007/s13300-020-00865-3

4. IDF. IDF diabetes atlas- 8th edition [EB/OL]; 2017. Available from: Accessed March 15, 2021.

5. Metzger BE, Lowe LP, Dyer AR, et al.; HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358(19):1991–2002. doi:10.1056/NEJMoa0707943

6. Horie I, Kawasaki E, Sakanaka A, et al. Efficacy of nutrition therapy for glucose intolerance in Japanese women diagnosed with gestational diabetes based on IADPSG criteria during early gestation. Diabetes Res Clin Pract. 2015;107(3):400–406. doi:10.1016/j.diabres.2014.12.011

7. American Diabetes Association. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2020. Diabetes Care. 2020;43(Suppl 1):S14–s31. doi:10.2337/dc20-S002

8. Hod M, Kapur A, Sacks DA, et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on gestational diabetes mellitus: a pragmatic guide for diagnosis, management, and care. Int J Gynaecol Obstet. 2015;131(Suppl 3):S173–s211.

9. Super DM, Edelberg SC, Philipson EH, Hertz RH, Kalhan SC. Diagnosis of gestational diabetes in early pregnancy. Diabetes Care. 1991;14(4):288–294. doi:10.2337/diacare.14.4.288

10. Hinkle SN, Tsai MY, Rawal S, Albert PS, Zhang C. HbA1c measured in the first trimester of pregnancy and the association with gestational diabetes. Sci Rep. 2018;8(1):12249. doi:10.1038/s41598-018-30833-8

11. Kattini R, Hummelen R, Kelly L. Early gestational diabetes mellitus screening with glycated hemoglobin: a systematic review. J Obstet Gynaecol Can. 2020;42(11):1379–1384. doi:10.1016/j.jogc.2019.12.015

12. Fong A, Serra AE, Gabby L, Wing DA, Berkowitz KM. Use of hemoglobin A1c as an early predictor of gestational diabetes mellitus. Am J Obstet Gynecol. 2014;211(6):641.e1–641.e7. doi:10.1016/j.ajog.2014.06.016

13. Rowan JA, Budden A, Ivanova V, Hughes RC, Sadler LC. Women with an HbA1c of 41–49 mmol/mol (5.9–6.6%): a higher risk subgroup that may benefit from early pregnancy intervention. Diabet Med. 2016;33(1):25–31. doi:10.1111/dme.12812

14. Pezeshki B, Chiti H, Arasteh P, Mazloomzadeh S. Early screening of gestational diabetes mellitus using hemoglobin A1C: revising current screening guidelines. Caspian J Intern Med. 2019;10(1):16–24. doi:10.22088/cjim.10.1.16

15. Amylidi S, Mosimann B, Stettler C, Fiedler GM, Surbek D, Raio L. First-trimester glycosylated hemoglobin in women at high risk for gestational diabetes. Acta Obstet Gynecol Scand. 2016;95(1):93–97. doi:10.1111/aogs.12784

16. Benaiges D, Flores-le Roux JA, Marcelo I, et al. Is first-trimester HbA1c useful in the diagnosis of gestational diabetes? Diabetes Res Clin Pract. 2017;133:85–91. doi:10.1016/j.diabres.2017.08.019

17. Arbib N, Shmueli A, Salman L, Krispin E, Toledano Y, Hadar E. First trimester glycosylated hemoglobin as a predictor of gestational diabetes mellitus. Int J Gynecol Obstet. 2019;145(2):158–163. doi:10.1002/ijgo.12794

18. Hughes RC, Moore MP, Gullam JE, Mohamed K, Rowan J. An early pregnancy HbA1c ≥5.9% (41 mmol/mol) is optimal for detecting diabetes and identifies women at increased risk of adverse pregnancy outcomes. Diabetes Care. 2014;37(11):2953–2959. doi:10.2337/dc14-1312

19. Kwon SS, Kwon JY, Park YW, Kim YH, Lim JB. HbA1c for diagnosis and prognosis of gestational diabetes mellitus. Diabetes Res Clin Pract. 2015;110(1):38–43. doi:10.1016/j.diabres.2015.07.014

20. Bender W, McCarthy C, Chittams J, et al. 189: what is the optimal Hemoglobin A1c screening cut-off for the prediction of gestational diabetes mellitus? Am J Obstet Gynecol. 2020;222(1):S132–S133. doi:10.1016/j.ajog.2019.11.205

21. Xiaoli Z, Li S, Xiying H. The Value of ROC curve on the glycated hemoglobin with gestational diabetes. Hebei Med. 2016;22(01):99–102.

22. Amaefule CE, Sasitharan A, Kalra P, et al. The accuracy of haemoglobin A1c as a screening and diagnostic test for gestational diabetes: a systematic review and meta-analysis of test accuracy studies. Curr Opin Obstet Gynecol. 2020;32(5):322–334. doi:10.1097/GCO.0000000000000648

23. Balaji V, Madhuri BS, Ashalatha S, Sheela S, Suresh S, Seshiah V. A1C in gestational diabetes mellitus in Asian Indian women. Diabetes Care. 2007;30(7):1865–1867. doi:10.2337/dc06-2329

23. Renz PB, Chume FC, Timm JRT, Pimentel AL, Camargo JL. Diagnostic accuracy of glycated hemoglobin for gestational diabetes mellitus: a systematic review and meta-analysis. Clin Chem Lab Med (CCLM). 2019;57(10):1435–1449. doi:10.1515/cclm-2018-1191

24. Ye M, Liu Y, Cao X, et al. The utility of HbA1c for screening gestational diabetes mellitus and its relationship with adverse pregnancy outcomes. Diabetes Res Clin Pract. 2016;114:43–49. doi:10.1016/j.diabres.2016.02.007

25. Rajput R, Yadav Y, Rajput M, Nanda S. Utility of HbA1c for diagnosis of gestational diabetes mellitus. Diabetes Res Clin Pract. 2012;98(1):104–107. doi:10.1016/j.diabres.2012.02.018

26. Tonguc M, Tayyar AT, Muderris I, Bayram F, Muhtaroglu S, Tayyar M. An evaluation of two different screening criteria in gestational diabetes mellitus. J Maternal Fetal Neonatal Med. 2018;31(9):1188–1193. doi:10.1080/14767058.2017.1311858

27. McFarland KF, Murtiashaw M, Baynes JW. Clinical value of glycosylated serum protein and glycosylated hemoglobin levels in the diagnosis of gestational diabetes mellitus. Obstet Gynecol. 1984;64(4):516–518.

28. Ryu AJ, Moon HJ, Na JO, et al. The usefulness of the glycosylated hemoglobin level for the diagnosis of gestational diabetes mellitus in the Korean Population. Diabetes Metab J. 2015;39(6):507–511. doi:10.4093/dmj.2015.39.6.507

29. Saglam B, Uysal S, Sozdinler S, Dogan OE, Onvural B. Diagnostic value of glycemic markers HbA1c, 1,5-anhydroglucitol and glycated albumin in evaluating gestational diabetes mellitus. Ther Adv Endocrinol Metab. 2017;8(12):161–167. doi:10.1177/2042018817742580

30. Ho YR, Wang P, Lu MC, Tseng ST, Yang CP, Yan YH. Associations of mid-pregnancy HbA1c with gestational diabetes and risk of adverse pregnancy outcomes in high-risk Taiwanese women. PLoS One. 2017;12(5):e0177563. doi:10.1371/journal.pone.0177563

31. Yexin Z, Haijun W, Hao H, Xiangyu Z. Significance of HbA1c and GA in initial screening of gestational diabetes mellitus. Lab Med. 2014;(11):1151–1153. doi:10.3969/j.issn.1673-8640.2014.11.22

32. Zhu J, Chen Y, Li C, Tao M, Teng Y. The diagnostic value of glycated albumin in gestational diabetes mellitus. J Endocrinol Invest. 2018;41(1):121–128. doi:10.1007/s40618-016-0605-7

33. Xiaoqing J, Yuanqiao W, Feng D, Nan Nan Z. Application of glycated albumin in primary screening of gestational diabetes. Chin J Health Lab Technol. 2019;29(18):2263–2264+2268.

34. Wu K, Cheng Y, Li T, et al. The utility of HbA1c combined with haematocrit for early screening of gestational diabetes mellitus. Diabetol Metab Syndr. 2018;10:14. doi:10.1186/s13098-018-0314-9

35. Yonghong P, Xiaoping W, Haiming T. Significance of HbA1c and GSP in diagnosis of gestational diabetes mellitus. Lab Med Clinic. 2015;(22):3366–3367, 3370. doi:10.3969/j.issn.1672-9455.2015.22.028

36. Shuangyan L, Jingyuan Z, Yajun Z, Xiaosu X. Glycosylated hemoglobin combined body mass index in early pregnancy screening for gestational diabetes mellitus. Chin J Birth Health Heredity. 2011;19(05):73–74+34.

37. Liwei C. Prediction of gestational diabetes mellitus in first trimester with body mass index,fasting blood glucose and glycosylated hemoglobin combined tests. J Pract Med. 2016;32(19):3120–3122.

38. Yuewen J, Chaoyan Y, Chunmei Y. Roles of glycated hemoglobin A1c and glycated albumin in screening gestational diabetes mellitus among elderly pregnant women. Lab Med. 2018;33(04):312–315.

39. Bin L, Huiqiong H. Application of glycosylated hemoglobin and glycosylated albumin in the screening of gestational diabetes mellitus. Labeled Immunoassays Clin Med. 2017;24(3):287–289. doi:10.11748/bjmy.issn.1006-1703.2017.03.012

40. Hua W, Jirong L, Jinting F, Tao Q. Clinical significance of glycosylated hemoglobin and super sensitive C protein in gestational diabetes mellitus. Labeled Immunoassays Clin Med. 2016;23(09):1049–1051.

41. Herman WH, Ma Y, Uwaifo G, et al.; Diabetes Prevention Program Research Group. Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention Program. Diabetes Care. 2007;30(10):2453–2457. doi:10.2337/dc06-2003

42. Barquiel B, Herranz L, Hillman N, et al. HbA1c and gestational weight gain are factors that influence neonatal outcome in mothers with gestational diabetes. J Womens Health (Larchmt). 2016;25(6):579–585. doi:10.1089/jwh.2015.5432

43. Hashimoto K, Koga M. Influence of iron deficiency on HbA1c levels in pregnant women: comparison with nonpregnant women. J Clin Med. 2018;7(2):pii: E34. doi:10.3390/jcm7020034.44

44. Lowe LP, Metzger BE, Dyer AR, et al.; HAPO Study Cooperative Research Group. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations of maternal A1C and glucose with pregnancy outcomes. Diabetes Care. 2012;35(3):574–580. doi:10.2337/dc11-1687

45. American Diabetes Association. 14. Management of diabetes in pregnancy: standards of medical care in diabetes-2019. Diabetes Care. 2019;42(Suppl1):S165–S172. doi:10.2337/dc19-S014.

46. Ezeaku EC, Alegbeleye JO, Bassey G. Relationship between glycosylated haemoglobin levels and perinatal outcome among women with gestational diabetes mellitus at the University of Port Harcourt Teaching Hospital, Nigeria. J Adv Med Med Res. 2020;54–63. doi:10.9734/jammr/2020/v32i730450

47. Sweeting AN, Ross GP, Hyett J, et al. Baseline HbA1c to identify high-risk gestational diabetes: utility in early vs standard gestational diabetes. J Clin Endocrinol Metab. 2017;102(1):150–156. doi:10.1210/jc.2016-2951

48. Morris MA, Grandis AS, Litton JC. Glycosylated hemoglobin concentration in early gestation associated with neonatal outcome. Am J Obstet Gynecol. 1985;153(6):651–654. doi:10.1016/s0002-9378(85)80253-2

49. Antoniou M, Gilbert L, Gross J, et al. Potentially modifiable predictors of adverse neonatal and maternal outcomes in pregnancies with gestational diabetes mellitus: can they help for future risk stratification and risk-adapted patient care? BMC Pregnancy Childbirth. 2019;19:469. doi:10.1186/s12884-019-2610-2

50. Kurishita M, Nakashima K, Kozu H. A retrospective study of glucose metabolism in mothers of large babies. Diabetes Care. 1994;17(7):649–652. doi:10.2337/diacare.17.7.649

51. Inkster ME, Fahey TP, Donnan PT, et al. Poor glycated haemoglobin control and adverse pregnancy outcomes in type 1 and type 2 diabetes mellitus: systematic review of observational studies. BMC Pregnancy Childbirth. 2006;6(1):50–55. doi:10.1186/1471-2393-6-30

52. Bi J, Ji C, Wu Y, et al. Association between maternal normal range HbA1c values and adverse birth outcomes. J Clin Endocrinol Metab. 2020;105(6):dgaa127. doi:10.1210/clinem/dgaa127

53. Li HP, Wang FH, Tao MF, Huang YJ, Jia WP. Association between glycemic control and birthweight with glycated albumin in Chinese women with gestational diabetes mellitus. J Diabetes Investig. 2016;7(1):48–55. doi:10.1111/jdi.12383

54. Sugawara D, Maruyama A, Imanishi T, Sugiyama Y, Ichihashi K. Complications in infants of diabetic mothers related to glycated albumin and hemoglobin levels during pregnancy. Pediatr Neonatol. 2016;57(6):496–500. doi:10.1016/j.pedneo.2016.02.003

55. Mendes N, Alves M, Andrade R, Ribeiro RT, Papoila AL, Serrano F. Association between glycated albumin, fructosamine, and HbA1c with neonatal outcomes in a prospective cohort of women with gestational diabetes mellitus. Int J Gynecol Obstet. 2019;146(3):326–332. doi:10.1002/ijgo.12897

56. Mañé L, Flores-le Roux JA, Benaiges D, et al. Role of first-trimester HbA1c as a predictor of adverse obstetric outcomes in a multiethnic cohort. J Clin Endocrinol Metab. 2017;102(2):390–397. doi:10.1210/jc.2016-2581

57. Qingchuan Z, Linhua Z, Huiqing W, Xianqun M. The changes of serum fasting blood glucose, 2h postprandial blood glucose and HbA1c levels of patients with gestational diabetes and their relationship with adverse pregnancy outcomes. J Clin Med Pract. 2017;21(24):23–26.

58. Ray JG, Davidson A, Berger H, Dayan N, Park AL. Haemoglobin levels in early pregnancy and severe maternal morbidity: population-based cohort study. BJOG. 2020;127(9):1154–1164. doi:10.1111/1471-0528.16216

59. Mañé L, Flores-le Roux JA, Gómez N, et al. Association of first-trimester HbA1c levels with adverse pregnancy outcomes in different ethnic groups. Diabetes Res Clin Pract. 2019;150:202–210. doi:10.1016/j.diabres.2019.03.017

60. Guerin A, Nisenbaum R, Ray JG. Use of maternal GHb concentration to estimate the risk of congenital anomalies in the offspring of women with prepregnancy diabetes. Diabetes Care. 2007;30(7):1920–1925. doi:10.2337/dc07-0278

61. McGrath RT, Glastras SJ, Seeho SK, Scott ES, Fulcher GR, Hocking SL. Association between glycemic variability, HbA1c, and large-for-gestational-age neonates in women with type 1 diabetes. Diabetes Care. 2017;40(8):e98–e100. doi:10.2337/dc17-0626

62. Lowe WL, Scholtens DM, Lowe LP, et al. Association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity. JAMA. 2018;320(10):1005–1016. doi:10.1001/jama.2018.11628

63. Goyal A, Gupta Y, Kalaivani M, et al. Long term (>1 year) postpartum glucose tolerance status among Indian women with history of Gestational Diabetes Mellitus (GDM) diagnosed by IADPSG criteria. Diabetes Res Clin Pract. 2018;142:154–161. doi:10.1016/j.diabres.2018.05.027

64. Retnakaran R, Qi Y, Sermer M, Connelly PW, Zinman B, Hanley AJ. Isolated hyperglycemia at 1 hour on oral glucose tolerance test in pregnancy resembles gestational diabetes mellitus in predicting postpartum metabolic dysfunction. Diabetes Care. 2008;31(7):1275–1281. doi:10.2337/dc08-0126

65. Kugishima Y, Yasuhi I, Yamashita H, et al. Risk factors associated with the development of postpartum diabetes in Japanese women with gestational diabetes. BMC Pregnancy Childbirth. 2018;18(1):19. doi:10.1186/s12884-017-1654-4

66. Katon J, Reiber G, Williams MA, Yanez D, Miller E. Hemoglobin A1c and postpartum abnormal glucose tolerance among women with gestational diabetes mellitus. Obstet Gynecol. 2012;119(3):566. doi:10.1097/AOG.0b013e3182475ac2

67. Katreddy MV, Pappachan JM, Taylor SE, Nevill AM, Indusekhar R, Nayak AU. Hemoglobin A1c in early postpartum screening of women with gestational diabetes. World J Diabetes. 2013;4(3):76–81. doi:10.4239/wjd.v4.i3.76

68. Kim C, Herman WH, Cheung NW, Gunderson EP, Richardson C. Comparison of hemoglobin A1c with fasting plasma glucose and 2-h postchallenge glucose for risk stratification among women with recent gestational diabetes mellitus. Diabetes Care. 2011;34(9):1949–1951. doi:10.2337/dc11-0269

69. Goyal A, Gupta Y, Kubihal S, Kalaivani M, Bhatla N, Tandon N. Utility of screening fasting plasma glucose and glycated hemoglobin to circumvent the need for oral glucose tolerance test in women with prior gestational diabetes. Adv Ther. 2021;38(2):1342–1351. doi:10.1007/s12325-020-01618-1

70. Megia A, Näf S, Herranz L, et al. The usefulness of HbA1c in postpartum reclassification of gestational diabetes. BJOG. 2012;119(7):891–894. doi:10.1111/j.1471-0528.2012.03325.x

71. Claire B, Sharon H. Should HbA1C be used to screen pregnant women for undiagnosed diabetes in the first trimester? A review of the evidence. J Public Health (Oxf). 2020;42(1):132–140. doi:10.1093/pubmed/fdy229

72. Salemans TH, van Dieijen-visser MP, Brombacher PJ. The value of HbA 1 and fructosamine in predicting impaired glucose tolerance—an alternative to OGTT to detect diabetes mellitus or gestational diabetes. Ann Clin Biochem. 1987;24(5):447–452. doi:10.1177/000456328702400504

73. Ryan EA, Stark R, Crockford PM, Suthijumroon A. Assessment of value of glycosylated albumin and protein in detection of gestational diabetes. Diabetes Care. 1987;10(2):213–216. doi:10.2337/diacare.10.2.213

74. Nielsen L, Ekbom P, Damm P, et al. HbA1c levels are significantly lower in early and late pregnancy. Diabetes Care. 2004;27(5):1200–1201. doi:10.2337/diacare.27.5.1200

75. Hiramatsu Y, Shimizu I, Omori Y, Nakabayashi M. Determination of reference intervals of glycated albumin and hemoglobin A1c in healthy pregnant Japanese women and analysis of their time courses and influencing factors during pregnancy. Endocr J. 2012;59:145–151. doi:10.1507/endocrj.K10E-410

76. Suh S, Joung JY, Jin SM, et al. Strong correlation between glycaemic variability and total glucose exposure in type 2 diabetes is limited to subjects with satisfactory glycaemic control. Diabetes Metab. 2014;40(4):272–277. doi:10.1016/j.diabet.2014.01.006

77. Mingzhen D. Application of serum glycated albumin in blood glucose monitoring during pregnancy. Med J Wuhan Univ. 2015;36(04):604–606+620.

78. de Veciana M, Major CA, Morgan MA, et al. Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy. N Engl J Med. 1995;333(19):1237–1241. doi:10.1056/NEJM199511093331901

79. Wong VW, Chong S, Mediratta S, Jalaludin B. Measuring glycated haemoglobin in women with gestational diabetes mellitus: how useful is it? Aust NZ J Obstet Gynecol. 2017;57(3):260–265. doi:10.1111/ajo.12511

80. Baxi L, Barad D, Reece EA, Farber R. Use of glycosylated hemoglobin as a screen for macrosomia in gestational diabetes. Obstet Gynecol. 1984;64(3):347–350.

81. Tang L, Xu S, Li P, Li L. Predictors of insulin treatment during pregnancy and abnormal postpartum glucose metabolism in patients with gestational diabetes mellitus. Diabetes Metabol Syndr Obes. 2019;12.

82. González-Quintero VH, Istwan NB, Rhea DJ, et al. Antenatal factors predicting subsequent need for insulin treatment in women with gestational diabetes. J Womens Health (Larchmt). 2008;17(7):1183–1187. doi:10.1089/jwh.2007.0667

83. Ducarme G, Desroys Du Roure F, Grange J, Vital M, Le Thuaut A, Crespin-Delcourt I. Predictive factors of subsequent insulin requirement for glycemic control during pregnancy at diagnosis of gestational diabetes mellitus. Int J Gynaecol Obstet. 2019;144(3):265–270. doi:10.1002/ijgo.12753

84. Bakiner O, Bozkirli E, Ozsahin K, Sariturk C, Ertorer E. Risk factors that can predict antenatal insulin need in gestational diabetes. J Clin Med Res. 2013;5(5):381–388. doi:10.4021/jocmr1515w

85. Skajaa GO, Kampmann U, Fuglsang J, Ovesen PG. High prepregnancy HbA1c is challenging to improve and affects insulin requirements, gestational length, and birthweight. J Diabetes. 2020;12:798–806. doi:10.1111/1753-0407.13070

86. Vintzileos AM, Thompson JP. Glycohemoglobin determinations in normal pregnancy and in insulin-dependent diabetics. Obstet Gynecol. 1980;56(4):435–439.

87. Pan J, Zhang F, Zhang L, Bao Y, Tao M, Jia W. Influence of insulin sensitivity and secretion on glycated albumin and hemoglobin A1c in pregnant women with gestational diabetes mellitus. Int J Gynaecol Obstet. 2013;121(3):252–256. doi:10.1016/j.ijgo.2013.01.017

88. Gomes D, von Kries R, Delius M, et al. Late-pregnancy dysglycemia in obese pregnancies after negative testing for gestational diabetes and risk of future childhood overweight: an interim analysis from a longitudinal mother-child cohort study. PLoS Med. 2018;15(10):e1002681. doi:10.1371/journal.pmed.1002681

89. Ensenauer R, Brandlhuber L, Burgmann M, et al. Obese nondiabetic pregnancies and high maternal glycated hemoglobin at delivery as an indicator of offspring and maternal postpartum risks: the prospective PEACHES mother-child cohort. Clin Chem. 2015;61(11):1381–1390. doi:10.1373/clinchem.2015.242206

90. Coustan DR, Lowe LP, Metzger BE, Dyer AR; International Association of Diabetes and Pregnancy Study Groups. The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: paving the way for new diagnostic criteria for gestational diabetes mellitus. Am J Obstet Gynecol. 2010;202(6):654. doi:10.1016/j.ajog.2010.04.006

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]